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ARHGAP5 Antikörper (AA 1102-1214)

ARHGAP5 Reaktivität: Human, Ratte, Hund WB, IF Wirt: Maus Monoclonal 54-P190 unconjugated
Produktnummer ABIN968611
  • Target Alle ARHGAP5 Antikörper anzeigen
    ARHGAP5 (rho GTPase Activating Protein 5 (ARHGAP5))
    Bindungsspezifität
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1102-1214
    Reaktivität
    • 21
    • 8
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Hund
    Wirt
    • 21
    Maus
    Klonalität
    • 19
    • 1
    Monoklonal
    Konjugat
    • 14
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser ARHGAP5 Antikörper ist unkonjugiert
    Applikation
    • 13
    • 6
    • 5
    • 3
    • 3
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Ratte (Rattus), Hund
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human p190-B aa. 1102-1214
    Klon
    54-P190
    Isotyp
    IgG1
    Top Product
    Discover our top product ARHGAP5 Primärantikörper
  • Kommentare

    Related Products: ABIN968533, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Burbelo, Finegold, Kozak, Yamada, Takami: "Cloning, genomic organization and chromosomal assignment of the mouse p190-B gene." in: Biochimica et biophysica acta, Vol. 1443, Issue 1-2, pp. 203-10, (1999) (PubMed).

    Burbelo, Miyamoto, Utani, Brill, Yamada, Hall, Yamada: "p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking." in: The Journal of biological chemistry, Vol. 270, Issue 52, pp. 30919-26, (1996) (PubMed).

  • Target
    ARHGAP5 (rho GTPase Activating Protein 5 (ARHGAP5))
    Andere Bezeichnung
    p190-B (ARHGAP5 Produkte)
    Synonyme
    gfi2 antikoerper, p190-b antikoerper, rhogap5 antikoerper, p190brhogap antikoerper, GFI2 antikoerper, RhoGAP5 antikoerper, p190-B antikoerper, p190BRhoGAP antikoerper, p190B antikoerper, LRRGT00098 antikoerper, Rho GTPase activating protein 5 antikoerper, ARHGAP5 antikoerper, arhgap5 antikoerper, Arhgap5 antikoerper
    Hintergrund
    GTPase activating proteins (GAPs) stimulate the GTP-hydrolyzing activity of GTPases, such as p21ras and Rho. p190-A is a Ras-GAP associated protein that is tyrosine phosphorylated in transformed and growth factor-stimulated cells. Ras-GAP and p190-A are targets of oncoproteins and growth factor receptors. p190-B is another Ras-GAP in the p190 family. It has 51% identity with p190-A and contains several GTPase-related domains in the N-terminal region and a Rho-GAP domain in the C-terminal region. p190-B is expressed in kidney, brain, liver, and lung, as well as in human foreskin fibroblasts, RD muscle cells, and HT-1080 cells. In fibroblasts, p190-B is localized diffusely in the cytoplasm and co-localizes with the alpha5beta1 integrin receptor for fibronectin. Adhesion of fibronectin-coated latex beads to cells leads to the recruitment of p190-B and Rho to the plasma membrane at sites of bead contact. In addition, the recombinant Rho-GAP domain of p190-B displays GAP activity for RhoA, Rac1, and G25K/CDC42Hs. Thus, p190-B is thought to act as a transmembrane link between integrins and Rho GTPases during fibronectin-induced changes in cell morphology and motility.
    Molekulargewicht
    190 kDa
    Pathways
    Regulation of Cell Size
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