MAPK8IP1 Antikörper (AA 180-384)

Produktnummer ABIN968696

Produktdetails anti-MAPK8IP1 Antikörper

Target: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Bindungsspezifität: AA 180-384

Reaktivität: Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAPK8IP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Fluorescence Microscopy (FM)

Kreuzreaktivität: Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse JIP-1 aa. 180-384

Klon: 50-JIP

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-MAPK8IP1 Antikörper (ABIN968696)

Meyer, Liu, Margolis: "Interaction of c-Jun amino-terminal kinase interacting protein-1 with p190 rhoGEF and its localization in differentiated neurons." in: The Journal of biological chemistry, Vol. 274, Issue 49, pp. 35113-8, (2000) (PubMed).

Bonny, Nicod, Waeber: "IB1, a JIP-1-related nuclear protein present in insulin-secreting cells." in: The Journal of biological chemistry, Vol. 273, Issue 4, pp. 1843-6, (1998) (PubMed).

Dickens, Rogers, Cavanagh, Raitano, Xia, Halpern, Greenberg, Sawyers, Davis: "A cytoplasmic inhibitor of the JNK signal transduction pathway." in: Science (New York, N.Y.), Vol. 277, Issue 5326, pp. 693-6, (1997) (PubMed).

Details zu MAPK8IP1

Target: MAPK8IP1 (Mitogen-Activated Protein Kinase 8 Interacting Protein 1 (MAPK8IP1))

Andere Bezeichnung: JIP-1 (MAPK8IP1 Produkte)

Synonyme: IB1 antikoerper, JIP-1 antikoerper, Jip1 antikoerper, Prkm8ip antikoerper, Skip antikoerper, mjip-2a antikoerper, JIP1 antikoerper, Jip-1 antikoerper, Mapk8ip antikoerper, PRKM8IP antikoerper, mitogen-activated protein kinase 8 interacting protein 1 antikoerper, MAPK8IP1 antikoerper, Mapk8ip1 antikoerper

Hintergrund: The JNK group of MAPKs is activated by a variety of inflammatory cytokines and environmental stressors. Activated JNK phosphorylates many cellular proteins, such as components of the AP-1 transcription factor complex (c-Jun and ATF-2). JNK-interacting proteins (JIPs) bind JNK, MKK7, MLKs, p190RhoGEF, and the Ste20-related protein kinase HPK1. In mouse, alternative splicing of JIP produces multiple splice variants, JIP-1, JIP-1b, JIP-2a, JIP-2b, and JIP-3. The structure of full length JIP consists of two N-terminal acidic regions, a JNK binding domain (JBD), two proline rich regions (PR), and both an SH3 and a phosphotyrosine-binding domain in the C-terminal region. JIP-1 localizes to the tips of neurites in differentiated PC12 cells, and may interact with JNK, MKK7, and MLK to facilitate formation of the JNK activating complex. IB1 is the rat homologue of JIP-1b, a JIP-1 variant that includes a 47 amino acid insert in the C-terminal region. IB1 is found in the nucleus and cytoplasm, and may function as a transactivator of the GLUT2 gene. Thus, JIP-1 and its related isoforms may have multiple functions that involve specific protein-protein interactions.
Synonyms: JNK Interacting Protein

Molekulargewicht: 112 kDa