MTTP Antikörper (AA 91-288)

Produktnummer ABIN968716

Produktdetails anti-MTTP Antikörper

Target: MTTP (Microsomal Triglyceride Transfer Protein (MTTP))

Bindungsspezifität: AA 91-288

Reaktivität: Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MTTP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse MTP aa. 91-288

Klon: 8-MTP

Isotyp: IgG2a

Anwendungsinformationen

Kommentare:

Related Products: ABIN968543, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-MTTP Antikörper (ABIN968716)

Chen, Newberry, Norris, Xie, Luo, Kennedy, Davidson: "ApoB100 is required for increased VLDL-triglyceride secretion by microsomal triglyceride transfer protein in ob/ob mice." in: Journal of lipid research, Vol. 49, Issue 9, pp. 2013-22, (2008) (PubMed).

Qin, Anderson, Adeli: "Tumor necrosis factor-alpha directly stimulates the overproduction of hepatic apolipoprotein B100-containing VLDL via impairment of hepatic insulin signaling." in: American journal of physiology. Gastrointestinal and liver physiology, Vol. 294, Issue 5, pp. G1120-9, (2008) (PubMed).

Morral, Edenberg, Witting, Altomonte, Chu, Brown: "Effects of glucose metabolism on the regulation of genes of fatty acid synthesis and triglyceride secretion in the liver." in: Journal of lipid research, Vol. 48, Issue 7, pp. 1499-510, (2007) (PubMed).

Read, Anderson, Ritchie, Vanloo, Amey, Levitt, Rosseneu, Scott, Shoulders: "A mechanism of membrane neutral lipid acquisition by the microsomal triglyceride transfer protein." in: The Journal of biological chemistry, Vol. 275, Issue 39, pp. 30372-7, (2000) (PubMed).

Wetterau, Gregg, Harrity, Arbeeny, Cap, Connolly, Chu, George, Gordon, Jamil, Jolibois, Kunselman, Lan, Maccagnan, Ricci, Yan, Young, Chen, Fryszman, Logan, Musial, Poss, Robl, Simpkins, Slusarchyk et al.: "An MTP inhibitor that normalizes atherogenic lipoprotein levels in WHHL rabbits. ..." in: Science (New York, N.Y.), Vol. 282, Issue 5389, pp. 751-4, (1998) (PubMed).

Nakamuta, Chang, Hoogeveen, Li, Chan: "Mouse microsomal triglyceride transfer protein large subunit: cDNA cloning, tissue-specific expression and chromosomal localization." in: Genomics, Vol. 33, Issue 2, pp. 313-6, (1997) (PubMed).

Details zu MTTP

Target: MTTP (Microsomal Triglyceride Transfer Protein (MTTP))

Andere Bezeichnung: MTP (MTTP Produkte)

Synonyme: ABL antikoerper, MTP antikoerper, 1810043K16Rik antikoerper, CG9342 antikoerper, CT3751 antikoerper, Dmel\\CG9342 antikoerper, dMTP antikoerper, wu:fd36b01 antikoerper, zgc:111876 antikoerper, microsomal triglyceride transfer protein antikoerper, Microsomal triacylglycerol transfer protein antikoerper, MTTP antikoerper, Mttp antikoerper, Mtp antikoerper, mttp antikoerper

Hintergrund: The microsomal triglyceride transfer protein (MTP) catalyzes the transport of triglyceride, cholesteryl ester, and phospholipid between membranes within the lumen of microsomes in hepatocytes and enterocytes. MTP forms a heterodimer with the 58 kDa protein disulfide isomerase. PDI catalyzes the isomerization of intramolecular disulfide bridges, thereby allowing them to generate their most thermodynamically stable configuration within proteins. MTP is mutated in abetalipoproteinemia, which results from defects in apolipoprotein-B (apoB)-containing lipoproteins. A lack of MTP expression prevents secretion of apoB from mammalian cells, leading to intracellular degradation. In the C-terminal region, MTP has structural homology to apoB and the lamprey lipovitellin protein. This region contains a membrane binding helix (Helix A), and a triglyceride binding helix (Helix B). Mutations in Helix B cause abetalipoproteinemia. In addition, inhibitors of MTP activity may be important therapeutics for lowering atherogenic lipoprotein levels. Thus, MTP is a microsomal protein that is required for transport of lipids between membranes in liver and small intestines.
Synonyms: Microsomal Triglyceride transfer Protein

Molekulargewicht: 97 kDa

Pathways: Transition Metal Ion Homeostasis