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CTBP1 Antikörper (AA 345-441)

CTBP1 Reaktivität: Human, Maus, Ratte, Hund, Huhn WB, IF Wirt: Maus Monoclonal 3-CtBP1 unconjugated
Produktnummer ABIN968722
  • Target Alle CTBP1 Antikörper anzeigen
    CTBP1 (C-terminal Binding Protein 1 (CTBP1))
    Bindungsspezifität
    • 26
    • 20
    • 8
    • 8
    • 7
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 345-441
    Reaktivität
    • 90
    • 55
    • 49
    • 17
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Hund, Huhn
    Wirt
    • 102
    • 5
    Maus
    Klonalität
    • 94
    • 13
    Monoklonal
    Konjugat
    • 59
    • 7
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CTBP1 Antikörper ist unkonjugiert
    Applikation
    • 69
    • 42
    • 26
    • 15
    • 15
    • 14
    • 14
    • 13
    • 5
    • 5
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Human, Ratte (Rattus), Huhn, Hund
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse CtBP1 aa. 345-441
    Klon
    3-CtBP1
    Isotyp
    IgG1
    Top Product
    Discover our top product CTBP1 Primärantikörper
  • Kommentare

    Related Products: ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Hildebrand, Soriano: "Overlapping and unique roles for C-terminal binding protein 1 (CtBP1) and CtBP2 during mouse development." in: Molecular and cellular biology, Vol. 22, Issue 15, pp. 5296-307, (2002) (PubMed).

    Muraoka, Ichikawa, Shi, Okumura, Taira, Higuchi, Hirano, Hibi, Miki: "Kheper, a novel ZFH/deltaEF1 family member, regulates the development of the neuroectoderm of zebrafish (Danio rerio)." in: Developmental biology, Vol. 228, Issue 1, pp. 29-40, (2001) (PubMed).

    Furusawa, Moribe, Kondoh, Higashi: "Identification of CtBP1 and CtBP2 as corepressors of zinc finger-homeodomain factor deltaEF1." in: Molecular and cellular biology, Vol. 19, Issue 12, pp. 8581-90, (2000) (PubMed).

    Schaeper, Boyd, Verma, Uhlmann, Subramanian, Chinnadurai: "Molecular cloning and characterization of a cellular phosphoprotein that interacts with a conserved C-terminal domain of adenovirus E1A involved in negative modulation of oncogenic transformation." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 23, pp. 10467-71, (1995) (PubMed).

  • Target
    CTBP1 (C-terminal Binding Protein 1 (CTBP1))
    Andere Bezeichnung
    CtBP1 (CTBP1 Produkte)
    Synonyme
    BARS antikoerper, CtBP1-L antikoerper, CtBP1-S antikoerper, CtBP3/BARS antikoerper, D4S115h antikoerper, D5H4S115 antikoerper, D5H4S115E antikoerper, 50-kDaBFA-inducedADP-ribosylatedsubstrate antikoerper, BARS-50 antikoerper, Bars antikoerper, wu:fi43a11 antikoerper, CtBP antikoerper, ctbp1-A antikoerper, xctbp1 antikoerper, bars antikoerper, CTBP1 antikoerper, C-terminal binding protein 1 antikoerper, C-terminal binding protein 1 L homeolog antikoerper, CTBP1 antikoerper, Ctbp1 antikoerper, ctbp1 antikoerper, ctbp1.L antikoerper
    Hintergrund
    Transcriptional repression is critical for genetic regulation of many cellular proteins, and involves either a transcription regulator that has an intrinsic repressor domain, or a transcription regulator that contains a binding site in the regulatory domain where a corepressor can bind. C-terminal binding proteins (CtBP1 and CtBP2) are a class of corepressors that interact with a subset of transcription factors through a PLDLSL sequence motif. CtBP1 and CtBP2 are 80% homologous, and both are expressed at high levels in embryonic tissues. However, CtBP1 is expressed higher in adult tissues, and is more widely expressed in embryonic and adult tissues. Both CtBP1 and CtBP2 bind the deltaEF1 zinc finger-homeodomain transcription factor, and enhance transcriptional repression via interaction with the PLDLSL-sequence in deltaEF1. CtBP1 and CtBP2 bind other zinc finger transcription factors, including Kheper and BKLF. In addition, CtBP2 interacts with other transcription factors, such as hFOG-2, Evi-1, AREB6, and ZEB. Thus, CtBP1 and CtBP2 may be important corepressors for a variety of transcriptional factors. This antibody is routinely tested by western blot analysis.
    Synonyms: C-terminal Binding Protein-1
    Molekulargewicht
    48 kDa
    Pathways
    Retinoic Acid Receptor Signaling Pathway
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