SRR Antikörper (AA 127-248)

Produktnummer ABIN968727

Produktdetails anti-SRR Antikörper

Target: SRR (Serine Racemase (SRR))

Bindungsspezifität: AA 127-248

Reaktivität: Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SRR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse serine racemase aa. 127-248

Klon: 29-Serine Racemase

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968540, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-SRR Antikörper (ABIN968727)

Mothet, Parent, Wolosker, Brady, Linden, Ferris, Rogawski, Snyder: "D-serine is an endogenous ligand for the glycine site of the N-methyl-D-aspartate receptor." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 9, pp. 4926-31, (2000) (PubMed).

Wolosker, Blackshaw, Snyder: "Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 23, pp. 13409-14, (1999) (PubMed).

Details zu SRR

Target: SRR (Serine Racemase (SRR))

Andere Bezeichnung: Serine Racemase (SRR Produkte)

Synonyme: DDBDRAFT_0188432 antikoerper, DDBDRAFT_0230209 antikoerper, DDB_0188432 antikoerper, DDB_0230209 antikoerper, ilv1 antikoerper, iso1 antikoerper, ILV1 antikoerper, ISO1 antikoerper, Srs antikoerper, serine racemase antikoerper, Serine racemase antikoerper, SRR antikoerper, srr antikoerper, NGR_b19540 antikoerper, ZPR_3642 antikoerper, MGYG_07950 antikoerper, Halhy_2637 antikoerper, Runsl_3290 antikoerper, Srr antikoerper

Hintergrund: The majority of synapses in the central nervous system utilize glutamate as a neurotransmitter to produce rapid neuronal excitation. Glutamate has a diverse array of receptors that can be categorized into two groups: ionotropic and metabotropic. The ionotropic receptors are subdivided into two distinct types: 1) receptors for N-methyl D-aspartate (NMDAR) and 2) non-NMDA receptors for AMPA and kainate. NMDA receptors require coactivation at both glutamate and glycine sites. D-serine is a D-amino acid found in mammalian tissues that can act as a potent ligand for the glycine site on NMDA receptors. D-serine is made by the enzyme serine racemase, which is a member of the pyridoxal-5' phosphate (PLP)-dependent enzyme family. Serine racemase mRNA is expressed in brain and liver, and serine racemase protein is expressed in glial cells. Degradation of D-serine by D-amino acid oxidase attenuates NMDA receptor-mediated calcium influx, and implicates D-serine as an endogenouse modulator of NMDA receptor function. Thus, glial cell production of D-serine via serine racemase activity may be an important system for modulation of synaptic transmission. This antibody is routinely tested by western blot analysis.

Molekulargewicht: 38 kDa