KIF1A Antikörper (AA 902-1015)

Produktnummer ABIN968736

Produktdetails anti-KIF1A Antikörper

Target: KIF1A (Kinesin Family Member 1A (KIF1A))

Bindungsspezifität: AA 902-1015

Reaktivität: Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KIF1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse KIF1A aa. 902-1015

Klon: 16-KIF1A

Isotyp: IgG1

Anwendungsinformationen

Kommentare:

Related Products: ABIN968545, ABIN967389

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-KIF1A Antikörper (ABIN968736)

Bloom: "The UNC-104/KIF1 family of kinesins." in: Current opinion in cell biology, Vol. 13, Issue 1, pp. 36-40, (2001) (PubMed).

Yonekawa, Harada, Okada, Funakoshi, Kanai, Takei, Terada, Noda, Hirokawa: "Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice." in: The Journal of cell biology, Vol. 141, Issue 2, pp. 431-41, (1998) (PubMed).

Okada, Yamazaki, Sekine-Aizawa, Hirokawa: "The neuron-specific kinesin superfamily protein KIF1A is a unique monomeric motor for anterograde axonal transport of synaptic vesicle precursors." in: Cell, Vol. 81, Issue 5, pp. 769-80, (1995) (PubMed).

Details zu KIF1A

Target: KIF1A (Kinesin Family Member 1A (KIF1A))

Andere Bezeichnung: KIF1A (KIF1A Produkte)

Synonyme: ATSV antikoerper, C630002N23Rik antikoerper, Gm1626 antikoerper, Kns1 antikoerper, C2orf20 antikoerper, HSN2C antikoerper, MRD9 antikoerper, SPG30 antikoerper, UNC104 antikoerper, kinesin family member 1A antikoerper, kinesin family member 1Aa antikoerper, KIF1A antikoerper, kif1a antikoerper, Kif1a antikoerper, kif1aa antikoerper

Hintergrund: The ability of the kinesin superfamily of motor proteins to hydrolyze ATP as they move progressively along microtubules is important for organelle transport and cell division. Kinesins are grouped according to the location of the motor domain in the N-terminal, middle, or C-terminal region of the protein. A family of N-terminal motor domain kinesin proteins includes KIF1A/1B, KIF3A/3B, KRP85/95, and Klp68d/64. KIF1A and KIF1B are 93% homologous in their N-terminal motor domains, however KIF1A contains a C-terminal PH domain. KIF1A and KIF1B are expressed in neurons where KIF1A is involved in fast anterograde axon transport of synaptic vesicles, and KIF1B is involved in anterograde axon transport of mitochondria. KIF1A associates with organelles that contain synaptotagmin, synaptophysin, and Rab3A. Disruption of the KIF1A gene in mice causes decreases in synaptic vesicle density, neuronal degeneration, and deficits in motor and sensory function. Thus, KIF1A is a critical brain motor protein involved with axonal transport of synaptic vesicle precursors. This antibody is routinely tested by western blot analysis.

Molekulargewicht: 200 kDa