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Sortilin 1 Antikörper (AA 300-422)

SORT1 Reaktivität: Human, Ratte, Maus, Hund, Huhn WB, IF Wirt: Maus Monoclonal 48-Neurotensin Receptor 3 unconjugated
Produktnummer ABIN968738
  • Target Alle Sortilin 1 (SORT1) Antikörper anzeigen
    Sortilin 1 (SORT1)
    Bindungsspezifität
    • 16
    • 6
    • 5
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 300-422
    Reaktivität
    • 44
    • 37
    • 31
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Ratte, Maus, Hund, Huhn
    Wirt
    • 47
    • 5
    • 2
    Maus
    Klonalität
    • 50
    • 4
    Monoklonal
    Konjugat
    • 24
    • 6
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Sortilin 1 Antikörper ist unkonjugiert
    Applikation
    • 37
    • 18
    • 17
    • 13
    • 13
    • 12
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    Kreuzreaktivität
    Maus, Ratte (Rattus), Hund, Huhn
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Human Neurotensin Receptor 3 aa. 300-422
    Klon
    48-Neurotensin Receptor 3
    Isotyp
    IgG1
    Top Product
    Discover our top product SORT1 Primärantikörper
  • Kommentare

    Related Products: ABIN968700, ABIN967389

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Nielsen, Jacobsen, Olivecrona, Gliemann, Petersen: "Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase." in: The Journal of biological chemistry, Vol. 274, Issue 13, pp. 8832-6, (1999) (PubMed).

    Mazella, Zsürger, Navarro, Chabry, Kaghad, Caput, Ferrara, Vita, Gully, Maffrand, Vincent: "The 100-kDa neurotensin receptor is gp95/sortilin, a non-G-protein-coupled receptor." in: The Journal of biological chemistry, Vol. 273, Issue 41, pp. 26273-6, (1998) (PubMed).

    Morris, Ross, Lane, Moestrup, Petersen, Keller, Lienhard: "Sortilin is the major 110-kDa protein in GLUT4 vesicles from adipocytes." in: The Journal of biological chemistry, Vol. 273, Issue 6, pp. 3582-7, (1998) (PubMed).

  • Target
    Sortilin 1 (SORT1)
    Andere Bezeichnung
    Neurotensin Receptor 3 (SORT1 Produkte)
    Synonyme
    SORT1 antikoerper, 19.m02079 antikoerper, gp95 antikoerper, ldlcq6 antikoerper, sortilin antikoerper, Gp95 antikoerper, LDLCQ6 antikoerper, NT3 antikoerper, 2900053A11Rik antikoerper, AI852375 antikoerper, Ntr3 antikoerper, Ntsr3 antikoerper, Nt3 antikoerper, Nts3 antikoerper, sort1 antikoerper, zgc:85953 antikoerper, sortilin 1 antikoerper, sortilin antikoerper, sortilin 1 S homeolog antikoerper, sortilin 1a antikoerper, SORT1 antikoerper, TP01_0016 antikoerper, BBOV_I002730 antikoerper, sort1.S antikoerper, Sort1 antikoerper, sort1a antikoerper
    Hintergrund
    Neurotensin (NT) is a neuropeptide that modulates dopaminergic transmission, triggers analgesic responses, induces hypotension, decreases gastric acid secretion, and activates lipid digestion. NT is a ligand for NT receptors, which include both G-protein coupled and non-G-protein coupled receptors. Neurotensin Receptor 3 (NTR3) is a non-G-protein coupled receptor that has a lumenal domain homologous to sorting proteins, and a short cytoplasmic tail homologous to mannose-6-phosphate/IGF-II receptor. NTR3 was also identified as sortilin/gp95, a component of GLUT4 vesicles in adipocytes that has been implicated in lipoprotein lipase degradation. NTR3 mRNA is expressed in brain, skeletal muscle, heart, and adipocytes. NTR3 mature protein has 44 N-terminal amino acid residues cleaved off, which may facilitate ligand binding to the receptor. Cellular localization of NTR3 is in the Golgi compartment and vesicles, as well as on the cell surface. In addition to roles in neuropeptide and lipoprotein degradation, NTR3 may also be involved in receptor protein sorting. Thus, NTR3 is a multifunctional transmembrane protein that acts as both a intracellular sorting receptor and extracellular ligand-binding receptor.
    Synonyms: NTR3
    Molekulargewicht
    95 kDa
    Pathways
    Neurotrophin Signalübertragung
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