MAPK14 Antikörper (pThr180)
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- Target Alle MAPK14 Antikörper anzeigen
- MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))
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Bindungsspezifität
- pThr180
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Reaktivität
- Human, Maus, Ratte
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser MAPK14 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
- Kreuzreaktivität
- Maus, Ratte (Rattus)
- Produktmerkmale
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols. - Aufreinigung
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human p38 MAPK (pT180/pY182)
- Klon
- 30-p38 MAPK
- Isotyp
- IgG1
- Top Product
- Discover our top product MAPK14 Primärantikörper
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- Kommentare
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Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968769
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 250 μg/mL
- Buffer
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
- Informationen zur Lagerung
- Store undiluted at -20°C.
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Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 9, pp. 4491-7, (1997) (PubMed).
: "Identification of MAP kinase domains by redirecting stress signals into growth factor responses." in: Science (New York, N.Y.), Vol. 272, Issue 5268, pp. 1652-5, (1996) (PubMed).
: "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells." in: Science (New York, N.Y.), Vol. 265, Issue 5173, pp. 808-11, (1994) (PubMed).
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Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 9, pp. 4491-7, (1997) (PubMed).
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- Target
- MAPK14 (Mitogen-Activated Protein Kinase 14 (MAPK14))
- Andere Bezeichnung
- p38 MAPK (MAPK14 Produkte)
- Synonyme
- CSBP antikoerper, CSBP1 antikoerper, CSBP2 antikoerper, CSPB1 antikoerper, EXIP antikoerper, Mxi2 antikoerper, PRKM14 antikoerper, PRKM15 antikoerper, RK antikoerper, SAPK2A antikoerper, p38 antikoerper, p38ALPHA antikoerper, CRK1 antikoerper, Csbp1 antikoerper, Csbp2 antikoerper, Exip antikoerper, Hog antikoerper, Prkm14 antikoerper, Prkm15 antikoerper, Sapk2A antikoerper, p38Hog antikoerper, p38alpha antikoerper, p38b antikoerper, zp38b antikoerper, MAPK14 antikoerper, 186F5S antikoerper, BG:DS00797.3 antikoerper, CG7393 antikoerper, D-p38 antikoerper, D-p38 MAPK antikoerper, D-p38b antikoerper, Dm p38b antikoerper, Dmel\\CG7393 antikoerper, Dmp38b antikoerper, Dp38 antikoerper, Dp38b antikoerper, ESTS:186F5S antikoerper, Mpk34C antikoerper, anon-sts23 antikoerper, dp38b antikoerper, p38 MAPK antikoerper, p38 beta antikoerper, p38B antikoerper, p38Kb antikoerper, p38beta antikoerper, Crk1 antikoerper, p38-alpha antikoerper, p38MAPK antikoerper, p38a antikoerper, csbp antikoerper, mapk14a antikoerper, mxi2 antikoerper, sapk2 antikoerper, sapk2a antikoerper, AP22.98 antikoerper, AP22_98 antikoerper, ATMPK14 antikoerper, mitogen-activated protein kinase 14 antikoerper, SAPK2a antikoerper, MAP kinase 14A antikoerper, MAP kinase p38a antikoerper, MAPK 14A antikoerper, fk28c03 antikoerper, hm:zeh1243 antikoerper, wu:fk28c03 antikoerper, zp38a antikoerper, P38C-CRK antikoerper, mitogen-activated protein kinase 14 antikoerper, mitogen activated protein kinase 14 antikoerper, mitogen-activated protein kinase 14b antikoerper, p38b MAP kinase antikoerper, mitogen-activated protein kinase 14 S homeolog antikoerper, mitogen-activated protein kinase 14a antikoerper, CRK proto-oncogene, adaptor protein antikoerper, MAPK14 antikoerper, Mapk14 antikoerper, mapk14b antikoerper, p38b antikoerper, mapk14.S antikoerper, MPK14 antikoerper, mapk14a antikoerper, CRK antikoerper
- Hintergrund
- Activation of the immune and inflammatory responses often involves the recognition of bacterial endotoxin (lipopolysaccharide or LPS). Binding of LPS by monocytic cells results in the production and release of proinflammatory cytokines, such as IL-1 and TNF-alpha. LPS-induced signaling cascades involve members of the Ser/Thr protein kinase family known as the mitogen activated protein kinases (MAPKs). MAPK signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation, and death. The p38 MAP kinases include p38alpha, beta, gamma, and delta. These ser/thr kinases are activated by dual phosphorylation on Thr and Tyr within the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the MAP kinase kinases, MKK3, MKK4, and MKK6. This leads to the activation of multiple transcription factors (NF-kappaB, ATF-2, Elk-1, and CHOP) that induce expression of many different genes, including proinflammatory cytokine genes. Thus, p38 MAPKs are central kinases in muliple signal transduction pathways.
- Molekulargewicht
- 38-42 kDa
- Pathways
- MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Regulation of Cell Size, Hepatitis C, Toll-Like Receptors Cascades, Autophagie, Thromboxane A2 Receptor Signaling, BCR Signaling, S100 Proteine
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