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TCAP Antikörper (AA 1-167)

TCAP Reaktivität: Human, Maus, Ratte WB Wirt: Maus Monoclonal 53-Telethonin unconjugated
Produktnummer ABIN968822
  • Target Alle TCAP Antikörper anzeigen
    TCAP (Titin-Cap (Telethonin) (TCAP))
    Bindungsspezifität
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-167
    Reaktivität
    • 25
    • 9
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 20
    • 6
    Maus
    Klonalität
    • 20
    • 6
    Monoklonal
    Konjugat
    • 19
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TCAP Antikörper ist unkonjugiert
    Applikation
    • 14
    • 8
    • 4
    • 2
    • 2
    • 1
    Western Blotting (WB)
    Kreuzreaktivität
    Human, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse Telethonin aa. 1-167
    Klon
    53-Telethonin
    Isotyp
    IgG1
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  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20°C.
  • Schröder, Reimann, Iakovenko, Mues, Bönnemann, Matten, Gautel: "Early and selective disappearance of telethonin protein from the sarcomere in neurogenic atrophy." in: Journal of muscle research and cell motility, Vol. 22, Issue 3, pp. 259-64, (2001) (PubMed).

    Moreira, Wiltshire, Faulkner, Nilforoushan, Vainzof, Suzuki, Valle, Reeves, Zatz, Passos-Bueno, Jenne: "Limb-girdle muscular dystrophy type 2G is caused by mutations in the gene encoding the sarcomeric protein telethonin." in: Nature genetics, Vol. 24, Issue 2, pp. 163-6, (2000) (PubMed).

    Mason, Bayol, Loughna: "The novel sarcomeric protein telethonin exhibits developmental and functional regulation." in: Biochemical and biophysical research communications, Vol. 257, Issue 3, pp. 699-703, (1999) (PubMed).

    Valle, Faulkner, De Antoni, Pacchioni, Pallavicini, Pandolfo, Tiso, Toppo, Trevisan, Lanfranchi: "Telethonin, a novel sarcomeric protein of heart and skeletal muscle." in: FEBS letters, Vol. 415, Issue 2, pp. 163-8, (1997) (PubMed).

  • Target
    TCAP (Titin-Cap (Telethonin) (TCAP))
    Andere Bezeichnung
    Telethonin (TCAP Produkte)
    Synonyme
    TCAP antikoerper, CMD1N antikoerper, LGMD2G antikoerper, T-cap antikoerper, TELE antikoerper, telethonin antikoerper, AI503981 antikoerper, AJ223855 antikoerper, titin-cap antikoerper, titin-cap (telethonin) antikoerper, titin-cap S homeolog antikoerper, TCAP antikoerper, tcap antikoerper, tcap.S antikoerper, Tcap antikoerper
    Hintergrund
    Autosomal recessive limb-girdle muscular dystrophy (AR LGMD), a genetically heterogeneous group of disorders affecting the proximal musculature, has eight distinct forms: 2A to 2H. Each of these forms is caused by specific gene mutations. A mutation in the telethonin gene causes LGMD 2G. Telethonin, a 19 kDa sarcomeric protein found in striated and cardiac muscle, has a developmentally and functionally regulated expression pattern. Telethonin transcript down-regulation occurs in response to muscle denervation. Protein levels of telethonin are partially regulated by neuronal activity, thereby linking telethonin to dynamic control of myofibrillogenesis and muscle turnover in human skeletal muscle. The telethonin transcript exhibits a pattern of accumulation typical of contractile proteins, suggesting a role for the protein in myofibrillar assembly. Immunofluorescence images show that telethonin co-localizes with myosin, which is an expression pattern typical of sarcomeric proteins. Telethonin has a known sarcomeric binding partner, titin, and is also known as titin CAP (TCAP). Therefore, telethonin plays a major role in AR LGMD 2G and is also important as a developmentally and functionally regulated sarcomeric protein.
    Molekulargewicht
    19 kDa
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