RUVBL2 Antikörper (AA 180-228)

Produktnummer ABIN968851

Produktdetails anti-RUVBL2 Antikörper

Target: RUVBL2 (RuvB-Like 2 (E. Coli) (RUVBL2))

Bindungsspezifität: AA 180-228

Reaktivität: Human, Maus, Ratte, Hund, Huhn

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RUVBL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Kreuzreaktivität: Hund, Ratte (Rattus), Maus, Huhn

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Human Reptin 52/TIF-496 aa. 180-228

Klon: 42-TIP49b

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20°C.

Referenzen für anti-RUVBL2 Antikörper (ABIN968851)

Cho, Bhoumik, Broday, Ivanov, Rosenstein, Ronai: "TIP49b, a regulator of activating transcription factor 2 response to stress and DNA damage." in: Molecular and cellular biology, Vol. 21, Issue 24, pp. 8398-413, (2001) (PubMed).

Bauer, Chauvet, Huber, Usseglio, Rothbächer, Aragnol, Kemler, Pradel: "Pontin52 and reptin52 function as antagonistic regulators of beta-catenin signalling activity." in: The EMBO journal, Vol. 19, Issue 22, pp. 6121-30, (2000) (PubMed).

Kanemaki, Kurokawa, Matsu-ura, Makino, Masani, Okazaki, Morishita, Tamura: "TIP49b, a new RuvB-like DNA helicase, is included in a complex together with another RuvB-like DNA helicase, TIP49a." in: The Journal of biological chemistry, Vol. 274, Issue 32, pp. 22437-44, (1999) (PubMed).

Details zu RUVBL2

Target: RUVBL2 (RuvB-Like 2 (E. Coli) (RUVBL2))

Andere Bezeichnung: TIP49b (RUVBL2 Produkte)

Synonyme: ECP51 antikoerper, INO80J antikoerper, REPTIN antikoerper, RVB2 antikoerper, TIH2 antikoerper, TIP48 antikoerper, TIP49B antikoerper, mp47 antikoerper, p47 antikoerper, reptin antikoerper, wu:fi25f01 antikoerper, zreptin antikoerper, MGC52995 antikoerper, tip48 antikoerper, xReptin antikoerper, rvb2 antikoerper, ecp51 antikoerper, cgi-46 antikoerper, tip49b antikoerper, MGC69398 antikoerper, RUVBL2 antikoerper, AAEL010341 antikoerper, Reptin antikoerper, rept antikoerper, RuvB like AAA ATPase 2 antikoerper, RuvB-like protein 2 antikoerper, RuvB-like AAA ATPase 2 antikoerper, RuvB like AAA ATPase 2 L homeolog antikoerper, ruvB-like 2 antikoerper, TATA box-binding protein antikoerper, ruvb-like 2 antikoerper, ruvB-like helicase 2 antikoerper, RUVBL2 antikoerper, Ruvbl2 antikoerper, ruvbl2 antikoerper, ruvbl2.L antikoerper, LOC726816 antikoerper, HBUT_RS02095 antikoerper, HAN_2g314 antikoerper, LOC100282179 antikoerper, LOC100284260 antikoerper, LOC5573243 antikoerper

Hintergrund: Processes involving DNA transcription, replication and repair are necessary in maintaining normal cell function. For each of these processes, the double stranded NA must first be unwound. This is achieved in an ATP-dependent manner by enzymes termed DNA helicases. Reptin52/TIP49b is a DNA helicase that directly interacts with Pontin52/TIP49a. Reptin52/TIP49b and Pontin52/TIP49a belong to a family of highly conserved proteins that share homology with the bacterial protein RuvB, a helicase involved in double-strand break repair and homologous recombination. Both are TATA binding protein (TBP) interacting proteins that bind to beta-Catenin and are among the 12 polypeptides that comprise the INO80 chromatin-remodeling complex. It has also been demonstrated that Reptin52/TIP49b and Pontin52/TIP49a can be found in a complex with the proto- ncogene c-myc. Reptin52/TIP49b and Pontin52/TIP49a have antagonistic roles as Reptin/TIP49b represses gene activation mediated by beta-Catenin and c-myc, whereas Pontin52/TIP49a stimulates gene activation. Thus, Reptin52/TIP49b and Pontin52/TIP49a are transcriptional co-factors that work together to help control multiple pathways.

Molekulargewicht: 52 kDa

Pathways: Telomere Maintenance