CTNND1 Antikörper (pTyr228)

Produktnummer ABIN968863

Produktdetails anti-CTNND1 Antikörper

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Bindungsspezifität: pTyr228

Reaktivität: Human, Maus, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CTNND1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)

Kreuzreaktivität: Human, Ratte (Rattus)

Produktmerkmale: 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Immunogen: Mouse p120 Catenin (pY228)

Klon: 21a-p120 Catenin

Isotyp: IgG1

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 250 μg/mL

Buffer: Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store undiluted at -20° C.

Referenzen für anti-CTNND1 Antikörper (ABIN968863)

Mariner, Anastasiadis, Keilhack, Böhmer, Wang, Reynolds: "Identification of Src phosphorylation sites in the catenin p120ctn." in: The Journal of biological chemistry, Vol. 276, Issue 30, pp. 28006-13, (2001) (PubMed).

Details zu CTNND1

Target: CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))

Andere Bezeichnung: p120 Catenin (CTNND1 Produkte)

Synonyme: CAS antikoerper, CTNND antikoerper, P120CAS antikoerper, P120CTN antikoerper, p120 antikoerper, p120(CAS) antikoerper, p120(CTN) antikoerper, Catns antikoerper, cas antikoerper, Xp120 antikoerper, ctnnd antikoerper, p120cas antikoerper, p120ctn antikoerper, p120(ctn) antikoerper, Xp120(ctn) antikoerper, p120-catenin antikoerper, CTNND1 antikoerper, AA409437 antikoerper, AU019353 antikoerper, Ctnnd antikoerper, P120 antikoerper, mKIAA0384 antikoerper, catenin delta 1 antikoerper, catenin (cadherin-associated protein), delta 1 antikoerper, catenin (cadherin associated protein), delta 1 antikoerper, catenin delta 1 L homeolog antikoerper, CTNND1 antikoerper, Ctnnd1 antikoerper, ctnnd1 antikoerper, ctnnd1.L antikoerper

Hintergrund: The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas)was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. This similarity is evidenced by its characteristic Arm domain that is composed of 42-amino acid motif repeats. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.

Molekulargewicht: 120 kDa

Pathways: EGFR Signaling Pathway, Neurotrophin Signalübertragung, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling