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CTNND1 Antikörper (pTyr228)

CTNND1 Reaktivität: Human, Maus, Ratte WB, IF, FACS Wirt: Maus Monoclonal 21a-p120 Catenin unconjugated
Produktnummer ABIN968863
  • Target Alle CTNND1 Antikörper anzeigen
    CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
    Bindungsspezifität
    • 22
    • 20
    • 17
    • 16
    • 15
    • 7
    • 7
    • 7
    • 6
    • 5
    • 5
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pTyr228
    Reaktivität
    • 142
    • 125
    • 53
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 149
    • 24
    Maus
    Klonalität
    • 145
    • 28
    Monoklonal
    Konjugat
    • 65
    • 12
    • 7
    • 6
    • 5
    • 5
    • 5
    • 5
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CTNND1 Antikörper ist unkonjugiert
    Applikation
    • 112
    • 54
    • 54
    • 45
    • 34
    • 30
    • 29
    • 23
    • 14
    • 14
    • 14
    • 4
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS)
    Kreuzreaktivität
    Human, Ratte (Rattus)
    Produktmerkmale
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Immunogen
    Mouse p120 Catenin (pY228)
    Klon
    21a-p120 Catenin
    Isotyp
    IgG1
    Top Product
    Discover our top product CTNND1 Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    250 μg/mL
    Buffer
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store undiluted at -20° C.
  • Mariner, Anastasiadis, Keilhack, Böhmer, Wang, Reynolds: "Identification of Src phosphorylation sites in the catenin p120ctn." in: The Journal of biological chemistry, Vol. 276, Issue 30, pp. 28006-13, (2001) (PubMed).

  • Target
    CTNND1 (Catenin (Cadherin-Associated Protein), delta 1 (CTNND1))
    Andere Bezeichnung
    p120 Catenin (CTNND1 Produkte)
    Synonyme
    CAS antikoerper, CTNND antikoerper, P120CAS antikoerper, P120CTN antikoerper, p120 antikoerper, p120(CAS) antikoerper, p120(CTN) antikoerper, Catns antikoerper, cas antikoerper, Xp120 antikoerper, ctnnd antikoerper, p120cas antikoerper, p120ctn antikoerper, p120(ctn) antikoerper, Xp120(ctn) antikoerper, p120-catenin antikoerper, CTNND1 antikoerper, AA409437 antikoerper, AU019353 antikoerper, Ctnnd antikoerper, P120 antikoerper, mKIAA0384 antikoerper, catenin delta 1 antikoerper, catenin (cadherin-associated protein), delta 1 antikoerper, catenin (cadherin associated protein), delta 1 antikoerper, catenin delta 1 L homeolog antikoerper, CTNND1 antikoerper, Ctnnd1 antikoerper, ctnnd1 antikoerper, ctnnd1.L antikoerper
    Hintergrund
    The membrane associated protein pp120 Src substrate (p120 Catenin, p120cas)was identified as a tyrosine kinase substrate that is phosphorylated in Src transformed cells or in response to growth factor stimulation. It shares structural similarity with the Drosophila Armadillo protein and the vertebrate beta-catenin and gamma-catenin proteins. This similarity is evidenced by its characteristic Arm domain that is composed of 42-amino acid motif repeats. In the cell, p120 Catenin is localized to the E-Cadherin/catenins cell adhesion complex. Like beta- and gamma-catenin, p120 Catenin directly associates with the cytoplasmic C-terminus of E-Cadherin via its Arm domain and may similarly interact with other Cadherins. It exists as four isoforms that range in size from 90-115kDa. Expression of these isoforms is heterogeneous in human carcinomas, suggesting that altered pp120 expression contributes to malignancy due to loss of functional cell adhesions. Multiple tyrosine residues (Y96, Y112, Y228, Y280, Y257, Y291, Y296, and Y302) in p120 Catenin are phosphorylated by Src and these phosphorylations may facilitate interaction with PTP1C/SHP-1 in response to EGF stimulation. Thus, p120 Catenin is an Arm domain protein that interacts with both cell adhesion molecules, such as cadherins and cell signaling molecules, such as PTP1C.
    Molekulargewicht
    120 kDa
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signalübertragung, Cell-Cell Junction Organization, CXCR4-mediated Signaling Events, Platelet-derived growth Factor Receptor Signaling
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