BMI1 Antikörper

Produktnummer ABIN968985

Produktdetails anti-BMI1 Antikörper

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BMI1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Verwendungszweck: BMI1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human BMI1 expressed in E. Coli.

Klon: 3E3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-BMI1 Antikörper (ABIN968985)

Edwards, Witherspoon, Wang, Afrasiabi, Pham, Birnbaumer, Lipkin: "Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer." in: Cancer research, Vol. 69, Issue 16, pp. 6423-9, (2009) (PubMed).

Bhattacharya, Nicoloso, Arvizo, Wang, Cortez, Rossi, Calin, Mukherjee: "MiR-15a and MiR-16 control Bmi-1 expression in ovarian cancer." in: Cancer research, Vol. 69, Issue 23, pp. 9090-5, (2009) (PubMed).

Details zu BMI1

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Andere Bezeichnung: BMI1 (BMI1 Produkte)

Synonyme: FLVI2/BMI1 antikoerper, PCGF4 antikoerper, RNF51 antikoerper, AW546694 antikoerper, Bmi-1 antikoerper, Pcgf4 antikoerper, bmi1 antikoerper, pcgf4 antikoerper, psc1 antikoerper, wu:fb17g03 antikoerper, wu:fd18f06 antikoerper, BMI-1 antikoerper, pcgf4b antikoerper, bmi-1 antikoerper, bmi1-a antikoerper, bmi1-b antikoerper, bmi1b antikoerper, rnf51 antikoerper, xbmi-1 antikoerper, BMI1 proto-oncogene, polycomb ring finger antikoerper, BMI1 polycomb ring finger oncogene antikoerper, Bmi1 polycomb ring finger oncogene antikoerper, bmi1 polycomb ring finger oncogene 1a antikoerper, bmi1 polycomb ring finger oncogene 1b antikoerper, BMI1 proto-oncogene, polycomb ring finger L homeolog antikoerper, BMI1 antikoerper, LOC100230513 antikoerper, Bmi1 antikoerper, bmi1a antikoerper, bmi1b antikoerper, bmi1.L antikoerper

Hintergrund:

Description: Component of the Polycomb group (PcG) multiprotein PRC1 complex, a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. In the PRC1 complex, it is required to stimulate the E3 ubiquitin-protein ligase activity of RNF2/RING2.

Aliases: PCGF4, RNF51, MGC12685, FLVI2/BMI1

Molekulargewicht: 37kDa

Gen-ID: 648

HGNC: 648

UniProt: P35226

Pathways: Zellzyklus, Autophagie