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BMX Antikörper

BMX Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 1C6 unconjugated
Produktnummer ABIN968989
  • Target Alle BMX Antikörper anzeigen
    BMX (BMX Non-Receptor Tyrosine Kinase (BMX))
    Reaktivität
    • 66
    • 58
    • 22
    • 6
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 80
    • 2
    Maus
    Klonalität
    • 80
    • 2
    Monoklonal
    Konjugat
    • 43
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BMX Antikörper ist unkonjugiert
    Applikation
    • 74
    • 36
    • 36
    • 26
    • 26
    • 24
    • 16
    • 7
    • 5
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human BMX expressed in E. coli.
    Klon
    1C6
    Isotyp
    IgG1
    Top Product
    Discover our top product BMX Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Palmer, Mutch, Workman, McDaid, Horwood, Foxwell: "Bmx tyrosine kinase regulates TLR4-induced IL-6 production in human macrophages independently of p38 MAPK and NFkapp}B activity." in: Blood, Vol. 111, Issue 4, pp. 1781-8, (2008) (PubMed).

    Côté, Motoyama, Bush, Vuori: "A novel and evolutionarily conserved PtdIns(3,4,5)P3-binding domain is necessary for DOCK180 signalling." in: Nature cell biology, Vol. 7, Issue 8, pp. 797-807, (2005) (PubMed).

  • Target
    BMX (BMX Non-Receptor Tyrosine Kinase (BMX))
    Andere Bezeichnung
    BMX (BMX Produkte)
    Synonyme
    BMX antikoerper, ETK antikoerper, PSCTK2 antikoerper, PSCTK3 antikoerper, Etk antikoerper, Etk/Bmx antikoerper, Tyro8 antikoerper, RGD1565643 antikoerper, BMX non-receptor tyrosine kinase antikoerper, BMX antikoerper, bmx antikoerper, Bmx antikoerper
    Hintergrund

    Description: BMX (bone marrow X kinase) is a cytoplasmic tyrosine kinase identified by reverse transcription of mRNA isolated from human bone marrow and mapped to the chromosomal band Xp22.2. The full length protein is 675 amino acids with a tyrosine kinase domain, an amino terminal pleckstrin domain, as well as an SH3 and SH2 domain. Direct comparison of BMX's primary sequence with other kinases showed that this is highly related to the family of BTK/ITK/TEC. BMX kinase is expressed in fetal and adult tissues, with the highest expression in heart, testis, small intestine and colon. It is undetectable in spleen, brain, kidney, and pancreas. Further analysis of mRNA expression showed that BMX is expressed in hematopoietic tissues and neutrophilic granulocytes, and in patients with acute and myeloid leukemia. The levels of BMX mRNA were substantially lower in patients with acute and chronic lymphoid leukemias, thus suggesting that BMX may be important during myelopoiesis.CST:It is expressed in a variety of hematopoietic, epithelial and endothelial cells.

    Aliases: ETK, PSCTK2, PSCTK3, BMX

    Molekulargewicht
    78 kDa
    Gen-ID
    660
    HGNC
    660
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