Integrin beta 2 Antikörper
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- Target Alle Integrin beta 2 (ITGB2) Antikörper anzeigen
- Integrin beta 2 (ITGB2)
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Integrin beta 2 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunocytochemistry (ICC)
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of CD18 expressed in E. coli.
- Klon
- 1-00E-13
- Isotyp
- IgG2b
- Top Product
- Discover our top product ITGB2 Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, ICC: 1:200 - 1:1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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The atypical zeta (zeta) isoform of protein kinase C regulates CD11b/CD18 activation in human neutrophils." in: Microcirculation (New York, N.Y. : 1994), Vol. 15, Issue 6, pp. 555-67, (2008) (PubMed).
: "The context of HLA-DR/CD18 complex in the plasma membrane governs HLA-DR-derived signals in activated monocytes." in: Molecular immunology, Vol. 45, Issue 3, pp. 709-18, (2007) (PubMed).
: "The cytosolic protein talin induces an intermediate affinity integrin alphaLbeta2." in: The Journal of biological chemistry, Vol. 282, Issue 33, pp. 24310-9, (2007) (PubMed).
: "
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The atypical zeta (zeta) isoform of protein kinase C regulates CD11b/CD18 activation in human neutrophils." in: Microcirculation (New York, N.Y. : 1994), Vol. 15, Issue 6, pp. 555-67, (2008) (PubMed).
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- Target
- Integrin beta 2 (ITGB2)
- Andere Bezeichnung
- CD18 (ITGB2 Produkte)
- Synonyme
- CD18 antikoerper, LAD antikoerper, LCAMB antikoerper, LFA-1 antikoerper, MAC-1 antikoerper, MF17 antikoerper, MFI7 antikoerper, 2E6 antikoerper, AI528527 antikoerper, Cd18 antikoerper, Lfa1 antikoerper, ITGB2 antikoerper, itgb2 antikoerper, itgb2-a antikoerper, itgb2-b antikoerper, integrin subunit beta 2 antikoerper, integrin beta 2 antikoerper, integrin subunit beta 2 S homeolog antikoerper, ITGB2 antikoerper, Itgb2 antikoerper, itgb2.S antikoerper
- Hintergrund
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Description: CD18, also known as ITGB2 (integrin beta chain beta 2). Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA-1, and combines with the alpha M chain to form the integrin Mac-1. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling. CD18 is expressed by most leucocytes. Defects in this gene are the cause of leukocyte adhesion deficiency type I (LAD1). Two transcript variants encoding the same protein have been identified for this gene.
Aliases: LAD, MF17, LCAMB, LFA-1, ITGB2
- Molekulargewicht
- 85 kDa
- Gen-ID
- 3689
- HGNC
- 3689
- Pathways
- NF-kappaB Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
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