CRTC1 Antikörper

Produktnummer ABIN969066

Produktdetails anti-CRTC1 Antikörper

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CRTC1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human CRTC1 expressed in E. coli. ,

Klon: 1B5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-CRTC1 Antikörper (ABIN969066)

Heinrich, Böer, Tzvetkov, Oetjen, Knepel: "Stimulation by lithium of the interaction between the transcription factor CREB and its co-activator TORC." in: Bioscience reports, Vol. 29, Issue 2, pp. 77-87, (2009) (PubMed).

Fehr, Röser, Belge, Löning, Bullerdiek: "A closer look at Warthin tumors and the t(11;19)." in: Cancer genetics and cytogenetics, Vol. 180, Issue 2, pp. 135-9, (2008) (PubMed).

Winnes, Mölne, Suurküla, Andrén, Persson, Enlund, Stenman: "Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas." in: Genes, chromosomes & cancer, Vol. 46, Issue 6, pp. 559-63, (2007) (PubMed).

Details zu CRTC1

Target: CRTC1 (CREB Regulated Transcription Coactivator 1 (CRTC1))

Andere Bezeichnung: CRTC1 (CRTC1 Produkte)

Synonyme: MECT1 antikoerper, TORC-1 antikoerper, TORC1 antikoerper, WAMTP1 antikoerper, AI413414 antikoerper, Mect1 antikoerper, R74955 antikoerper, mKIAA0616 antikoerper, CRTC1 antikoerper, crtc1 antikoerper, fc68c05 antikoerper, pde4cb antikoerper, si:ch211-255d18.1 antikoerper, si:ch211-255d18.8 antikoerper, wu:fc68c05 antikoerper, CREB regulated transcription coactivator 1 antikoerper, CREB regulated transcription coactivator 1b antikoerper, CRTC1 antikoerper, Crtc1 antikoerper, crtc1 antikoerper, crtc1b antikoerper

Hintergrund:

Description: MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1) functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1 does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11,19) (q21,p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein. Tissue specificity: Highly expressed in adult and fetal brain. Located to specific regions such as the prefrontal cortex and cerebellum. Very low expression in other tissues such as heart, spleen, lung, skeletal muscle, salivary gland, ovary and kidney.

Aliases: MECT1, TORC1, WAMTP1, FLJ14027, KIAA0616, CRTC1

Molekulargewicht: 67 kDa

Gen-ID: 23373

HGNC: 23373