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ErbB2/Her2 Antikörper (AA 750-987)

ErbB2/Her2 Reaktivität: Human WB, ELISA, IHC, FACS Wirt: Maus Monoclonal 6C2 unconjugated
Produktnummer ABIN969111
  • Target Alle ErbB2/Her2 Antikörper anzeigen
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Bindungsspezifität
    • 31
    • 29
    • 29
    • 29
    • 26
    • 26
    • 22
    • 22
    • 16
    • 15
    • 13
    • 13
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    AA 750-987
    Reaktivität
    • 518
    • 188
    • 166
    • 32
    • 8
    • 5
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 410
    • 154
    • 10
    • 5
    • 3
    • 3
    Maus
    Klonalität
    • 416
    • 166
    • 2
    Monoklonal
    Konjugat
    • 268
    • 45
    • 37
    • 28
    • 23
    • 22
    • 10
    • 10
    • 9
    • 9
    • 9
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    Dieser ErbB2/Her2 Antikörper ist unkonjugiert
    Applikation
    • 294
    • 228
    • 139
    • 97
    • 93
    • 93
    • 91
    • 80
    • 61
    • 51
    • 30
    • 21
    • 12
    • 9
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)
    Verwendungszweck
    ERBB2 Antibody
    Aufreinigung
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human ERBB2(aa750-987) expressed in E. Coli.
    Klon
    6C2
    Isotyp
    IgG1
    Top Product
    Discover our top product ErbB2/Her2 Primärantikörper
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Yamauchi, Stearns, Hayes: "When is a tumor marker ready for prime time? A case study of c-erbB-2 as a predictive factor in breast cancer." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 19, Issue 8, pp. 2334-56, (2001) (PubMed).

  • Target
    ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
    Andere Bezeichnung
    ERBB2 (ErbB2/Her2 Produkte)
    Synonyme
    CD340 antikoerper, HER-2 antikoerper, HER-2/neu antikoerper, HER2 antikoerper, MLN 19 antikoerper, NEU antikoerper, NGL antikoerper, TKR1 antikoerper, Erbb-2 antikoerper, Neu antikoerper, c-erbB2 antikoerper, c-neu antikoerper, mKIAA3023 antikoerper, wu:fv70f10 antikoerper, zgc:63601 antikoerper, erb2 antikoerper, erb-b2 receptor tyrosine kinase 2 antikoerper, ERBB2 antikoerper, Erbb2 antikoerper, erbb2 antikoerper
    Hintergrund

    Description: ERBB2: v-erb-b2 erythroblastic leukemia viral oncogene homolog 2, neuro/glioblastoma derived oncogene homolog (avian). This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

    Aliases: NEU, HER2, TKR1, CD340, HER-2

    Molekulargewicht
    180kDa
    Gen-ID
    2064
    HGNC
    2064
    UniProt
    P04626
    Pathways
    RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Skeletal Muscle Fiber Development
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