ERBB3 Antikörper (AA 22-369)

Produktnummer ABIN969114

Produktdetails anti-ERBB3 Antikörper

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Bindungsspezifität: AA 22-369

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ERBB3 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC)

Verwendungszweck: ERBB3 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human ERBB3 (aa22-369) fused with hIgGFc tag expressed in HEK293 cells.

Klon: 2F9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-ERBB3 Antikörper (ABIN969114)

Sassen, Rochon, Wild, Hartmann, Hofstaedter, Schwarz, Brockhoff: "Cytogenetic analysis of HER1/EGFR, HER2, HER3 and HER4 in 278 breast cancer patients." in: Breast cancer research : BCR, Vol. 10, Issue 1, pp. R2, (2008) (PubMed).

Sakai, Yokote, Murakami-Murofushi, Tamura, Saijo, Nishio: "Pertuzumab, a novel HER dimerization inhibitor, inhibits the growth of human lung cancer cells mediated by the HER3 signaling pathway." in: Cancer science, Vol. 98, Issue 9, pp. 1498-503, (2007) (PubMed).

Details zu ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Andere Bezeichnung: ERBB3 (ERBB3 Produkte)

Synonyme: ErbB-3 antikoerper, HER3 antikoerper, LCCS2 antikoerper, MDA-BF-1 antikoerper, c-erbB-3 antikoerper, c-erbB3 antikoerper, erbB3-S antikoerper, p180-ErbB3 antikoerper, p45-sErbB3 antikoerper, p85-sErbB3 antikoerper, ERBB3 antikoerper, C76256 antikoerper, Erbb-3 antikoerper, Erbb3r antikoerper, Her3 antikoerper, nuc-ErbB3 antikoerper, erb-b2 receptor tyrosine kinase 3 antikoerper, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) antikoerper, ERBB3 antikoerper, Erbb3 antikoerper

Hintergrund:

Description:

ERBB3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian). It is a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.

Aliases: HER3, c-erbB3

Molekulargewicht: 148kDa

Gen-ID: 2065

HGNC: 2065

UniProt: P21860

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung