ETV4 Antikörper (AA 50-109)

Produktnummer ABIN969121

Produktdetails anti-ETV4 Antikörper

Target: ETV4 (Ets Variant 4 (ETV4))

Bindungsspezifität: AA 50-109

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ETV4 Antikörper ist unkonjugiert

Applikation: ELISA

Verwendungszweck: ETV4 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human ETV4 (aa50-109) expressed in E. Coli.

Klon: 1A2G3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-ETV4 Antikörper (ABIN969121)

Yu, Xia, Wang, Wang, Pan, Kwong, Hortobagyi, Hung: "Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1." in: Molecular carcinogenesis, Vol. 45, Issue 9, pp. 667-75, (2006) (PubMed).

Matsui, Sugimori, Motomura, Ejiri, Tsukada, Kitajima: "PEA3 cooperates with c-Jun in regulation of HER2/neu transcription." in: Oncology reports, Vol. 16, Issue 1, pp. 153-8, (2006) (PubMed).

Zhu, Jiang, Shen, Wang, Zong, Li, Yang, Niu, Liu, Chen, Hu, Gu: "Elevated beta1,4-galactosyltransferase I in highly metastatic human lung cancer cells. Identification of E1AF as important transcription activator." in: The Journal of biological chemistry, Vol. 280, Issue 13, pp. 12503-16, (2005) (PubMed).

Details zu ETV4

Target: ETV4 (Ets Variant 4 (ETV4))

Andere Bezeichnung: ETV4 (ETV4 Produkte)

Synonyme: E1A-F antikoerper, E1AF antikoerper, PEA3 antikoerper, PEAS3 antikoerper, Pea3 antikoerper, AW414408 antikoerper, Pea-3 antikoerper, pea3 antikoerper, ETS variant 4 antikoerper, ets variant 4 antikoerper, ETV4 antikoerper, Etv4 antikoerper, etv4 antikoerper

Hintergrund:

Description: ETV4: ets variant gene 4 (E1A enhancer binding protein, E1AF), also known as PEA3. Several members of the Ets gene family are known to encode sequencespecific DNA binding proteins. These include mouse PU.1, mouse and human Ets-1, Drosophila E74, chicken and human Ets-2 and rat GABP-a. Each of these proteins recognizes similar motifs in DNA that share a centrally located 5'-GGAA-3' element. For instance, PEA3 binds the motif 5'-AGGAAG-3' (the PEA-3 motif), but does not bind to the sequence 5'-AGGAAC-3', recognized by PU.1, although PU.1 binds equally well to both sequences. It appears that all of the Ets proteins recognize the same central core sequence but that each protein interacts with unique sequences that flank this core. PEA3 is expressed at readily detectable levels in cells of epithelial and fibroblastic origin but is not expressed in hematopoietic cells. This is in contrast to other members of the Ets gene family, such as Ets-1, Ets-2 and Fli-1, each of which is expressed primarily in cells of hematopoietic origin.

Aliases: HGK, NIK, PEA3

Molekulargewicht: 54kDa

Gen-ID: 2118

HGNC: 2118

UniProt: P43268