FAK Antikörper

Produktnummer ABIN969129

Produktdetails anti-FAK Antikörper

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser FAK Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Verwendungszweck: FAK Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human FAK expressed in E. Coli.

Klon: 10H7E9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-FAK Antikörper (ABIN969129)

Tse, Dang-Lawson, Lee, Vong, Bulic, Buckbinder, Gold: "B cell receptor-induced phosphorylation of Pyk2 and focal adhesion kinase involves integrins and the Rap GTPases and is required for B cell spreading." in: The Journal of biological chemistry, Vol. 284, Issue 34, pp. 22865-77, (2009) (PubMed).

Zheng, Kurenova, Ucar, Golubovskaya, Magis, Ostrov, Cance, Hochwald: "Targeting of the protein interaction site between FAK and IGF-1R." in: Biochemical and biophysical research communications, Vol. 388, Issue 2, pp. 301-5, (2009) (PubMed).

Details zu FAK

Target: FAK (PTK2) (PTK2 Protein tyrosine Kinase 2 (PTK2))

Andere Bezeichnung: FAK (PTK2 Produkte)

Synonyme: FADK antikoerper, FAK antikoerper, FAK1 antikoerper, FRNK antikoerper, PPP1R71 antikoerper, p125FAK antikoerper, pp125FAK antikoerper, PTK2 antikoerper, Fadk antikoerper, mKIAA4203 antikoerper, fak antikoerper, fak1a antikoerper, ptk2 antikoerper, ptk2a antikoerper, wu:fa18c04 antikoerper, zgc:66114 antikoerper, CG10023 antikoerper, CT28129 antikoerper, DFAK antikoerper, DFak antikoerper, DFak56 antikoerper, Dfak antikoerper, Dfak56 antikoerper, DmFAK antikoerper, Dmel\\CG10023 antikoerper, Fak56 antikoerper, Fak56D antikoerper, fak56 antikoerper, protein tyrosine kinase 2 antikoerper, protein tyrosine kinase 2 L homeolog antikoerper, PTK2 protein tyrosine kinase 2 antikoerper, protein tyrosine kinase 2ab antikoerper, Focal adhesion kinase antikoerper, PTK2 antikoerper, ptk2.L antikoerper, Ptk2 antikoerper, ptk2ab antikoerper, Fak antikoerper

Hintergrund:

Description: This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. At least four transcript variants encoding four different isoforms have been found for this gene, but the full-length natures of only two of them have been determined. Tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.RD: Focal adhesion kinase 1 (FAK) is a ubiquitously expressed non-receptor protein tyrosine kinase that is concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. This cellular localization is directed by a

Aliases: FAK, FADK, FAK1, FRNK, pp125FAK, PTK2

Molekulargewicht: 119kDa

Gen-ID: 5747

HGNC: 5747

UniProt: Q05397

Pathways: Response to Growth Hormone Stimulus, CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling