GPI Antikörper

Produktnummer ABIN969176

Produktdetails anti-GPI Antikörper

Target: GPI (Glucose-6-Phosphate Isomerase (GPI))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GPI Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Verwendungszweck: Glucose-6-phosphate isomerase Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human GPI expressed in E. Coli.

Klon: 1B7D7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-GPI Antikörper (ABIN969176)

Schaller, Stohl, Benoit, Tan, Johansen, Ditzel: "Patients with inflammatory arthritic diseases harbor elevated serum and synovial fluid levels of free and immune-complexed glucose-6-phosphate isomerase (G6PI)." in: Biochemical and biophysical research communications, Vol. 349, Issue 2, pp. 838-45, (2006) (PubMed).

Haga, Komazaki, Funasaka, Hashimoto, Yokoyama, Watanabe, Raz, Nagase: "AMF/G6PI induces differentiation of leukemic cells via an unknown receptor that differs from gp78." in: Leukemia & lymphoma, Vol. 47, Issue 10, pp. 2234-43, (2006) (PubMed).

Muraki, Matsumoto, Chino, Hayashi, Suzuki, Goto, Ito, Murata, Tsutsumi, Sumida: "Glucose-6-phosphate isomerase variants play a key role in the generation of anti-GPI antibodies: possible mechanism of autoantibody production." in: Biochemical and biophysical research communications, Vol. 323, Issue 2, pp. 518-22, (2004) (PubMed).

Details zu GPI

Target: GPI (Glucose-6-Phosphate Isomerase (GPI))

Andere Bezeichnung: Glucose-6-phosphate isomerase (GPI Produkte)

Substanzklasse: Viral Protein

Hintergrund:

Description: Glucose-6-phosphate isomerase, or phosphoglucose isomerase, also known as GPI. It belongs to the GPI family whose members encode multifunctional phosphoglucose isomerase proteins involved in energy pathways and it is an enzyme that catalyzes the conversion of glucose-6-phosphate into fructose 6-phosphate in the second step of glycolysis. The protein functions in different capacities inside and outside the cell. In the cytoplasm, the gene product is involved in glycolysis and gluconeogenesis, while outside the cell it functions as a neurotrophic factor for spinal and sensory neurons. Defects in GPI are the cause of nonspherocytic hemolytic anemia and a severe enzyme deficiency can be associated with hydrops fetalis, immediate neonatal death and neurological impairment.

Aliases: AMF, NLK, PGI, PHI, GNPI, SA-36, GPI

Molekulargewicht: 63kDa

Gen-ID: 2821

HGNC: 2821

UniProt: P06744