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GRK2 Antikörper

ADRBK1 Reaktivität: Human, Maus, Ratte, Affe WB, ELISA, IHC, ICC Wirt: Maus Monoclonal 3F8 unconjugated
Produktnummer ABIN969178
  • Target Alle GRK2 (ADRBK1) Antikörper anzeigen
    GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
    Reaktivität
    • 101
    • 79
    • 58
    • 9
    • 7
    • 6
    • 4
    • 4
    • 4
    • 2
    • 2
    • 1
    Human, Maus, Ratte, Affe
    Wirt
    • 95
    • 8
    • 2
    • 2
    Maus
    Klonalität
    • 91
    • 16
    Monoklonal
    Konjugat
    • 61
    • 7
    • 6
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GRK2 Antikörper ist unkonjugiert
    Applikation
    • 58
    • 45
    • 33
    • 19
    • 14
    • 13
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human GRK2 expressed in E. coli.
    Klon
    3F8
    Isotyp
    IgG1
    Top Product
    Discover our top product ADRBK1 Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Sterne-Marr, Leahey, Bresee, Dickson, Ho, Ragusa, Donnelly, Amie, Krywy, Brookins-Danz, Orakwue, Carr, Yoshino-Koh, Li, Tesmer: "GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail." in: Biochemistry, Vol. 48, Issue 20, pp. 4285-93, (2009) (PubMed).

    Chen, Long, Wu, Jiang, Ma: "EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2973-83, (2008) (PubMed).

  • Target
    GRK2 (ADRBK1) (Adrenergic, Beta, Receptor Kinase 1 (ADRBK1))
    Andere Bezeichnung
    GRK2 (ADRBK1 Produkte)
    Synonyme
    Adrbk-1 antikoerper, Bark-1 antikoerper, GRK2 antikoerper, betaARK1 antikoerper, BARK1 antikoerper, BETA-ARK1 antikoerper, GRK-2 antikoerper, Grk2 antikoerper, beta-adrenergic receptor kinase 1 antikoerper, G protein-coupled receptor kinase 2 antikoerper, Tsp_00497 antikoerper, grk2 antikoerper, Grk2 antikoerper, GRK2 antikoerper
    Hintergrund

    Description: The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of beta-adrenergic receptor to G protein is involved in the pathogenesis of the failing heart. (provided by RefSeq)Tissue specificity: Expressed in peripheral blood leukocytes

    Aliases: GRK2, BARK1, FLJ16718, BETA-ARK1, ADRBK1

    Molekulargewicht
    80 kDa
    Gen-ID
    156
    HGNC
    156
    Pathways
    EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
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