HAS1 Antikörper

Produktnummer ABIN969185

Produktdetails anti-HAS1 Antikörper

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser HAS1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC)

Verwendungszweck: HAS1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human HAS1 expressed in E. Coli.

Klon: 3E10

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-HAS1 Antikörper (ABIN969185)

Stuhlmeier: "Hyaluronan production in synoviocytes as a consequence of viral infections: HAS1 activation by Epstein-Barr virus and synthetic double- and single-stranded viral RNA analogs." in: The Journal of biological chemistry, Vol. 283, Issue 24, pp. 16781-9, (2008) (PubMed).

Adamia, Treon, Reiman, Tournilhac, McQuarrie, Mant, Belch, Pilarski: "Potential impact of a single nucleotide polymorphism in the hyaluronan synthase 1 gene in Waldenstrom's macroglobulinemia." in: Clinical lymphoma, Vol. 5, Issue 4, pp. 253-6, (2005) (PubMed).

Details zu HAS1

Target: HAS1 (Hyaluronan Synthase 1 (HAS1))

Andere Bezeichnung: HAS1 (HAS1 Produkte)

Synonyme: dg42 antikoerper, Xhas1 antikoerper, HAS antikoerper, shas1 antikoerper, hyaluronan synthase 1 antikoerper, hyaluronan synthase 1 S homeolog antikoerper, has1 antikoerper, HAS1 antikoerper, Has1 antikoerper, has1.S antikoerper

Hintergrund:

Description: Hyaluronan or hyaluronic acid (HA) is a high molecular weight unbranched polysaccharide synthesized by a wide variety of organisms from bacteria to mammals, and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked by beta-1-3 and beta-1-4 glycosidic bonds. HA is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded through pore-like structures into the extracellular space. It serves a variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. HA is actively produced during wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in the serum concentration of HA are associated with inflammatory and degenerative arthropathies such as rheumatoid arthritis. In addition, the interaction of HA with the leukocyte receptor CD44 is important in tissue-specific homing by leukocytes, and overexpression of HA receptors has been correlated with tumor metastasis. HAS1 is a member of the newly identified vertebrate gene family encoding putative hyaluronan synthases, and its amino acid sequence shows significant homology to the hasA gene product of Streptococcus pyogenes, a glycosaminoglycan synthetase (DG42) from Xenopus laevis, and a recently described murine hyaluronan synthase.

Aliases: HAS, HAS1

Molekulargewicht: 65kDa

Gen-ID: 3036

HGNC: 3036

UniProt: Q92839

Pathways: Glycosaminoglycan Metabolic Process