Hexokinase 1 Antikörper

Produktnummer ABIN969194

Produktdetails anti-Hexokinase 1 Antikörper

Target: Hexokinase 1 (HK1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Hexokinase 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Verwendungszweck: HK1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human HK1 expressed in E. Coli.

Klon: 7A7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Hexokinase 1 Antikörper (ABIN969194)

Martins-de-Souza, Gattaz, Schmitt, Rewerts, Marangoni, Novello, Maccarrone, Turck, Dias-Neto: "Alterations in oligodendrocyte proteins, calcium homeostasis and new potential markers in schizophrenia anterior temporal lobe are revealed by shotgun proteome analysis." in: Journal of neural transmission (Vienna, Austria : 1996), Vol. 116, Issue 3, pp. 275-89, (2009) (PubMed).

Tsai: "Function of interdomain alpha-helix in human brain hexokinase: covalent linkage and catalytic regulation between N- and C-terminal halves." in: Journal of biomedical science, Vol. 14, Issue 2, pp. 195-202, (2007) (PubMed).

Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: "A human protein-protein interaction network: a resource for annotating the proteome. ..." in: Cell, Vol. 122, Issue 6, pp. 957-68, (2005) (PubMed).

Details zu Hexokinase 1

Target: Hexokinase 1 (HK1)

Andere Bezeichnung: HK1 (HK1 Produkte)

Hintergrund:

Description: The hexokinases utilize Mg-ATP as a phosphoryl donor to catalyze the first step of intracellular glucose metabolism, the conversion of glucose to glucose- 6-phosphate. Four hexokinase isoenzymes have been identified, including hexokinase I (HXK I), hexokinase II (HXK II), hexokinase III (HXK III) and hexokinase IV (HXK IV, also designated glucokinase or GCK). Hexokinases I-III each contain an N-terminal cluster of hydrophobic amino acids. Glucokinase lacks the N-terminal hydrophobic cluster. The hydrophobic cluster is thought to be necessary for membrane binding. This is substantiated by the finding that glucokinase has lower affinity for glucose than do the other hexokinases. HK I has been shown to be expressed in brain, kidney and heart tissues as well as in hepatoma cell lines.

Aliases: HKI, HXK1, HK1-ta, HK1-tb, HK1-tc, HK1

Molekulargewicht: 102kDa

Gen-ID: 3098

HGNC: 3098

UniProt: P19367

Pathways: Carbohydrate Homeostasis, Warburg Effekt