IRAK4 Antikörper

Produktnummer ABIN969218

Produktdetails anti-IRAK4 Antikörper

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IRAK4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Verwendungszweck: IRAK4 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human IRAK4 expressed in E. Coli.

Klon: 2H9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-IRAK4 Antikörper (ABIN969218)

Dunne, Carpenter, Brikos, Gray, Strelow, Wesche, Morrice, ONeill: "IRAK1 and IRAK4 promote phosphorylation, ubiquitination, and degradation of MyD88 adaptor-like (Mal)." in: The Journal of biological chemistry, Vol. 285, Issue 24, pp. 18276-82, (2010) (PubMed).

Pathak, De Souza, Salte, Wiker, Asjö: "HIV induces both a down-regulation of IRAK-4 that impairs TLR signalling and an up-regulation of the antibiotic peptide dermcidin in monocytic cells." in: Scandinavian journal of immunology, Vol. 70, Issue 3, pp. 264-76, (2009) (PubMed).

Details zu IRAK4

Target: IRAK4 (Interleukin-1 Receptor-Associated Kinase 4 (IRAK4))

Andere Bezeichnung: IRAK4 (IRAK4 Produkte)

Synonyme: zgc:55553 antikoerper, IRAK4 antikoerper, ipd1 antikoerper, irak-4 antikoerper, ny-ran-64 antikoerper, ny-ren-64 antikoerper, ren64 antikoerper, irak4 antikoerper, IPD1 antikoerper, IRAK-4 antikoerper, NY-REN-64 antikoerper, REN64 antikoerper, 8430405M07Rik antikoerper, 9330209D03Rik antikoerper, interleukin 1 receptor associated kinase 4 antikoerper, interleukin-1 receptor-associated kinase 4 antikoerper, IRAK4 antikoerper, irak4 antikoerper, Irak4 antikoerper

Hintergrund:

Description: This gene encodes a kinase that activates NF-kappaB in both the Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. The protein is essential for most innate immune responses. Mutations in this gene result in IRAK4 deficiency and recurrent invasive pneumococcal disease. Multiple transcript variants encoding different isoforms have been found for this gene.

Aliases: IPD1, REN64, NY-REN-64

Molekulargewicht: 52kDa

Gen-ID: 51135

HGNC: 51135

UniProt: Q9NWZ3

Pathways: NF-kappaB Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades