KDM3A Antikörper

Produktnummer ABIN969229

Produktdetails anti-KDM3A Antikörper

Target: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KDM3A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunocytochemistry (ICC)

Verwendungszweck: KDM3A Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human KDM3A expressed in E. Coli.

Klon: 2E1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-KDM3A Antikörper (ABIN969229)

Sobral, Sechler, Parrish, McCann, Jones, Black, Jedlicka: "KDM3A/Ets1/MCAM axis promotes growth and metastatic properties in Rhabdomyosarcoma." in: Genes & cancer, Vol. 11, Issue 1-2, pp. 53-65, (2020) (PubMed).

Sechler, Parrish, Birks, Jedlicka: "The histone demethylase KDM3A, and its downstream target MCAM, promote Ewing Sarcoma cell migration and metastasis." in: Oncogene, Vol. 36, Issue 29, pp. 4150-4160, (2017) (PubMed).

Hillier, Graves, Fulton, Fulton, Pepin, Minx, Wagner-McPherson, Layman, Wylie, Sekhon, Becker, Fewell, Delehaunty, Miner, Nash, Kremitzki, Oddy, Du, Sun, Bradshaw-Cordum, Ali, Carter, Cordes, Harris et al.: "Generation and annotation of the DNA sequences of human chromosomes 2 and 4. ..." in: Nature, Vol. 434, Issue 7034, pp. 724-31, (2005) (PubMed).

Nagase, Ishikawa, Suyama, Kikuno, Miyajima, Tanaka, Kotani, Nomura, Ohara: "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro." in: DNA research : an international journal for rapid publication of reports on genes and genomes, Vol. 5, Issue 5, pp. 277-86, (1999) (PubMed).

Details zu KDM3A

Target: KDM3A (Lysine (K)-Specific Demethylase 3A (KDM3A))

Andere Bezeichnung: KDM3A (KDM3A Produkte)

Synonyme: JHDM2A antikoerper, JHMD2A antikoerper, JMJD1 antikoerper, JMJD1A antikoerper, TSGA antikoerper, tsga antikoerper, jmjd1 antikoerper, jhdm2a antikoerper, jhmd2a antikoerper, jmjd1a antikoerper, 1700105C21Rik antikoerper, C230043E16Rik antikoerper, JHDM2a antikoerper, Jmjd1 antikoerper, Jmjd1a antikoerper, KDM2A antikoerper, TGSA antikoerper, Tsga antikoerper, mKIAA0742 antikoerper, KDM3A antikoerper, kdm3a antikoerper, lysine demethylase 3A antikoerper, lysine (K)-specific demethylase 3A antikoerper, lysine-specific demethylase 3A antikoerper, lysine (K)-specific demethylase 3A S homeolog antikoerper, KDM3A antikoerper, kdm3a antikoerper, Kdm3a antikoerper, LOC100453519 antikoerper, kdm3a.S antikoerper

Hintergrund:

Description: This gene encodes a zinc finger protein that contains a jumonji domain and may play a role in hormone-dependent transcriptional activation. JMJD1A functions as a mono- and dimethylation-specific demethylase, binding iron and alpha-ketoglutarate as cofactors and demethylating Lysine 9 of Histone H3. This suggests that JMJD1A plays a central role in the histone code and participates in nuclear hormone receptor-based transcriptional regulation. In addition, JMJD1A plays an important role in the regulation of cell growth during development and in chromatin regulation. JMJD1A directly regulates the expression of TNP1 and Protamine 1 (proteins required for the proper packaging and condensation of sperm chromatin) and, therefore, plays an essential role in spermatogenesis.

Aliases: TSGA, JMJD1, JHDM2A, JHMD2A, JMJD1A, KIAA0742, DKFZp686A24246, DKFZp686P07111, KDM3A

Molekulargewicht: 147kDa

Gen-ID: 55818

HGNC: 55818

UniProt: Q9Y4C1

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Nuclear Hormone Receptor Binding, Warburg Effekt