KLHL13 Antikörper

Produktnummer ABIN969245

Produktdetails anti-KLHL13 Antikörper

Target: KLHL13 (Kelch-Like 13 (KLHL13))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KLHL13 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human KLHL13 expressed in E. coli.

Klon: 8D1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-KLHL13 Antikörper (ABIN969245)

Jin, Pahuja, Wickliffe, Gorur, Baumgärtel, Schekman, Rape: "Ubiquitin-dependent regulation of COPII coat size and function." in: Nature, Vol. 482, Issue 7386, pp. 495-500, (2012) (PubMed).

Suzuki, Yamashita, Shirota, Sakakibara, Chiba, Mizushima-Sugano, Nakai, Sugano: "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions." in: Genome research, Vol. 14, Issue 9, pp. 1711-8, (2004) (PubMed).

Details zu KLHL13

Target: KLHL13 (Kelch-Like 13 (KLHL13))

Andere Bezeichnung: KLHL13 (KLHL13 Produkte)

Synonyme: 1200009K10Rik antikoerper, AI451128 antikoerper, Bklhd2 antikoerper, D130072F20Rik antikoerper, mKIAA1309 antikoerper, BKLHD2 antikoerper, Kelch-like protein 13 antikoerper, kelch-like 13 antikoerper, kelch like family member 13 antikoerper, kelch like family member 9 antikoerper, kelch-like family member 13 antikoerper, klh13 antikoerper, Klhl13 antikoerper, KLHL13 antikoerper, KLHL9 antikoerper

Hintergrund:

Description: KLHL13 (kelch-like 13), also known as BKLHD2 (BTB and kelch domain-containing protein 2), is a 604 amino acid protein that contains six Kelch repeats and one BTB/POZ domain. Expressed predominantly in brain, KLHL13 is believed to play a role in protein ubiquitination and may function as a substrate- specific adapter of an E3 ubiquitin-protein ligase complex. E3 ligases accept a ubiquitin residue from an E2 ubiquitin-conjugating enzyme and immediately transfer that residue to a protein that is targeted for degradation. Specifically, KLHL13 interacts with KLHL9 and CUL-3, a member of the cullin family of mediators that participate in the selective targeting of proteins for ubiquitin-mediated proteolysis. Via its BTB and C-terminal Kelch (BACK) motif, KLHL13 is thought to play a role in spatially orientating substrates in the CUL-3 ligase.

Aliases: BKLHD2, FLJ10262, MGC74791, KLHL13

Molekulargewicht: 74 kDa

Gen-ID: 90293

HGNC: 90293