Laminin beta 1 Antikörper (AA 31-270)

Produktnummer ABIN969256

Produktdetails anti-Laminin beta 1 Antikörper

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Bindungsspezifität: AA 31-270

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Laminin beta 1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Verwendungszweck: LAMB1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of LAMB1 (aa31-270) expressed in E. Coli.

Klon: 2D9G5

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Laminin beta 1 Antikörper (ABIN969256)

Fujita, Khazenzon, Bose, Sekiguchi, Sasaki, Carter, Ljubimov, Black, Ljubimova: "Overexpression of beta1-chain-containing laminins in capillary basement membranes of human breast cancer and its metastases." in: Breast cancer research : BCR, Vol. 7, Issue 4, pp. R411-21, (2005) (PubMed).

Virtanen, Korhonen, Petäjäniemi, Karhunen, Thornell, Sorokin, Konttinen: "Laminin isoforms in fetal and adult human adrenal cortex." in: The Journal of clinical endocrinology and metabolism, Vol. 88, Issue 10, pp. 4960-6, (2003) (PubMed).

Details zu Laminin beta 1

Target: Laminin beta 1 (LAMB1) (Laminin, beta 1 (LAMB1))

Andere Bezeichnung: LAMB1 (LAMB1 Produkte)

Synonyme: CLM antikoerper, LIS5 antikoerper, fc20b05 antikoerper, gup antikoerper, lamb1 antikoerper, sb:cb95 antikoerper, wu:fc20b05 antikoerper, Lamb1-1 antikoerper, LAMB1 antikoerper, C77966 antikoerper, C80098 antikoerper, C81607 antikoerper, D130003D08Rik antikoerper, Lamb-1 antikoerper, laminin subunit beta 1 antikoerper, laminin, beta 1a antikoerper, laminin B1 antikoerper, LAMB1 antikoerper, lamb1a antikoerper, Lamb1 antikoerper, lamb1 antikoerper

Hintergrund:

Description: LAMB1: laminin, beta 1. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Aliases: CLM, MGC142015

Gen-ID: 3912

HGNC: 3912

UniProt: P07942