MAP2K4 Antikörper

Produktnummer ABIN969268

Produktdetails anti-MAP2K4 Antikörper

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAP2K4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Verwendungszweck: MAP2K4 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human MAP2K4 expressed in E. Coli.

Klon: 5H4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MAP2K4 Antikörper (ABIN969268)

Song, Coffa, Fu, Gurevich: "How does arrestin assemble MAPKs into a signaling complex?" in: The Journal of biological chemistry, Vol. 284, Issue 1, pp. 685-95, (2008) (PubMed).

Yoshizawa, Hammaker, Sweeney, Boyle, Firestein: "Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 5, pp. 3252-8, (2008) (PubMed).

Details zu MAP2K4

Target: MAP2K4 (Mitogen-Activated Protein Kinase Kinase 4 (MAP2K4))

Andere Bezeichnung: MAP2K4 (MAP2K4 Produkte)

Hintergrund:

Description: This gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.Tissue specificity: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues .

Aliases: JNKK, MEK4, MKK4, SEK1, JNKK1, SERK1, MAPKK4, PRKMK4, MAP2K4

Molekulargewicht: 42kDa

Gen-ID: 6416

HGNC: 6416

UniProt: P45985

Pathways: MAPK Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling