MAP2K7 Antikörper

Produktnummer ABIN969271

Produktdetails anti-MAP2K7 Antikörper

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAP2K7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Aufreinigung: purified

Immunogen: Purified recombinant fragment of human MAP2K7 expressed in E. coli.

Klon: 4-00E-05

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: 4°C, -20°C for long term storage

Referenzen für anti-MAP2K7 Antikörper (ABIN969271)

Nakagawa, Sugahara, Yamasaki, Kajiho, Takahashi, Hirayama, Minami, Ohta, Watanabe, Hata, Katada, Nishina: "Filamin associates with stress signalling kinases MKK7 and MKK4 and regulates JNK activation." in: The Biochemical journal, Vol. 427, Issue 2, pp. 237-45, (2010) (PubMed).

Yoshizawa, Hammaker, Sweeney, Boyle, Firestein: "Synoviocyte innate immune responses: I. Differential regulation of interferon responses and the JNK pathway by MAPK kinases." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 5, pp. 3252-8, (2008) (PubMed).

Details zu MAP2K7

Target: MAP2K7 (Mitogen-Activated Protein Kinase Kinase 7 (MAP2K7))

Andere Bezeichnung: MAP2K7 (MAP2K7 Produkte)

Synonyme: MAP2K7 antikoerper, 2 antikoerper, JNKK antikoerper, Jnkk2 antikoerper, Mapkk7 antikoerper, Mek7 antikoerper, Mkk7 antikoerper, MAPKK7 antikoerper, MKK7 antikoerper, PRKMK7 antikoerper, SAPKK-4 antikoerper, SAPKK4 antikoerper, 5930412N11Rik antikoerper, JNKK 2 antikoerper, MAPKK 7 antikoerper, MEK 7 antikoerper, Prkmk7 antikoerper, sek2 antikoerper, si:ch211-254d18.2 antikoerper, map2k7-A antikoerper, mitogen-activated protein kinase kinase 7 antikoerper, mitogen activated protein kinase kinase 7 antikoerper, mitogen-activated protein kinase kinase 7 L homeolog antikoerper, MAP2K7 antikoerper, Map2k7 antikoerper, map2k7 antikoerper, map2k7.L antikoerper

Hintergrund:

Description: The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.

Aliases: MKK7, Jnkk2, MAPKK7, PRKMK7

Molekulargewicht: 48 kDa

Gen-ID: 5609

HGNC: 5609

Pathways: MAPK Signalweg, TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades, BCR Signaling