MCM2 Antikörper

Produktnummer ABIN969280

Produktdetails anti-MCM2 Antikörper

Target: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MCM2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)

Verwendungszweck: MCM2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human MCM2 expressed in E. Coli.

Klon: 2B3

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MCM2 Antikörper (ABIN969280)

Chuang, Teixeira, Wohlschlegel, Henze, Yates, Méndez, Reed: "Phosphorylation of Mcm2 by Cdc7 promotes pre-replication complex assembly during cell-cycle re-entry." in: Molecular cell, Vol. 35, Issue 2, pp. 206-16, (2009) (PubMed).

Liaw, Boyd: "MCM 2 Expression in Basal Cell Carcinomas and Trichoepitheliomas." in: Journal of cutaneous pathology, Vol. 36, Issue 10, pp. 1121-2, (2009) (PubMed).

Details zu MCM2

Target: MCM2 (Minichromosome Maintenance Complex Component 2 (MCM2))

Andere Bezeichnung: MCM2 (MCM2 Produkte)

Synonyme: CG7538 antikoerper, DmMCM2 antikoerper, DmMcm2 antikoerper, DmeMCM2 antikoerper, Dmel\\CG7538 antikoerper, MCM2 antikoerper, MCM2-7 antikoerper, MCM2_DROME antikoerper, McM2 antikoerper, PCR3 antikoerper, dMCM2 antikoerper, l(3)rL074 antikoerper, XMcm2 antikoerper, bm28 antikoerper, ccnl1 antikoerper, cdc19 antikoerper, cdcl1 antikoerper, mitotin antikoerper, cb737 antikoerper, chunp6905 antikoerper, BM28 antikoerper, CCNL1 antikoerper, CDCL1 antikoerper, D3S3194 antikoerper, MITOTIN antikoerper, MCM7 antikoerper, AA959861 antikoerper, AW476101 antikoerper, Mcmd2 antikoerper, mKIAA0030 antikoerper, Minichromosome maintenance 2 antikoerper, minichromosome maintenance complex component 2 antikoerper, minichromosome maintenance complex component 2 L homeolog antikoerper, Mcm2 antikoerper, mcm2 antikoerper, MCM2 antikoerper, mcm2.L antikoerper

Hintergrund:

Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7.

Aliases: BM28, CCNL1, CDCL1, cdc19, D3S3194, MITOTIN, KIAA0030, MGC10606

Molekulargewicht: 125kDa

Gen-ID: 4171

HGNC: 4171

UniProt: P49736

Pathways: DNA Reparatur, Mitotic G1-G1/S Phases, DNA Replication, Chromatin Binding, Synthesis of DNA