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MLH1 Antikörper (AA 381-483)

MLH1 Reaktivität: Human, Affe WB, ELISA, IHC, ICC Wirt: Maus Monoclonal 4C9C7 unconjugated
Produktnummer ABIN969285
  • Target Alle MLH1 Antikörper anzeigen
    MLH1 (MutL Homolog 1 (MLH1))
    Bindungsspezifität
    • 15
    • 10
    • 6
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 381-483
    Reaktivität
    • 79
    • 22
    • 21
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Affe
    Wirt
    • 63
    • 16
    Maus
    Klonalität
    • 57
    • 22
    Monoklonal
    Konjugat
    • 49
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MLH1 Antikörper ist unkonjugiert
    Applikation
    • 43
    • 30
    • 15
    • 13
    • 13
    • 12
    • 10
    • 8
    • 6
    • 6
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Verwendungszweck
    MLH1 Antibody
    Aufreinigung
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of MLH1 (aa381-483) expressed in E. Coli.
    Klon
    4C9C7
    Isotyp
    IgG1
    Top Product
    Discover our top product MLH1 Primärantikörper
  • Applikationshinweise

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Geary, Sasieni, Houlston, Izatt, Eeles, Payne, Fisher, Hodgson: "Gene-related cancer spectrum in families with hereditary non-polyposis colorectal cancer (HNPCC)." in: Familial cancer, Vol. 7, Issue 2, pp. 163-72, (2008) (PubMed).

    Latta, Mohan, Issekutz: "CXCR6 is expressed on T cells in both T helper type 1 (Th1) inflammation and allergen-induced Th2 lung inflammation but is only a weak mediator of chemotaxis." in: Immunology, Vol. 121, Issue 4, pp. 555-64, (2007) (PubMed).

    Zeng, Kinsella: "A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells." in: Autophagy, Vol. 3, Issue 4, pp. 368-70, (2007) (PubMed).

  • Target
    MLH1 (MutL Homolog 1 (MLH1))
    Andere Bezeichnung
    MLH1 (MLH1 Produkte)
    Hintergrund

    Description: DNA-mismatch repair (MMR), a conserved process that involves correcting errors made during DNA synthesis, is crucial to the maintenance of genomic integrity. Lack of a functional DNA-mismatch repair pathway is a common characteristic of several different types of human cancers, either due to an MMR gene mutation or promoter-methylation gene silencing. MLH1 is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+ phenotype) found in hereditary nonpolyposis colon cancer (HNPCC). MLH1 is an integral part of the protein complex responsible for mismatch repair expressed in lymphocytes, heart, colon, breast, lung, spleen, testis, prostate, thyroid and gall bladder, and is methylated in several ovarian tumors. Loss of MLH1 protein expression is associated with a mutated phenotype, microsatellite instability and a predisposition to cancer. In hereditary nonpolyposis colorectal cancer (HNPCC), an autosomal dominant inherited cancer syndrome that signifies a high risk of colorectal and various other types of cancer, the MLH1 gene exhibits a pathogenic mutation. Inactivation of the MLH1 gene causes genome instability and predisposition to cancer. MLH1 also plays a role in meiotic recombination.

    Aliases: FCC2, COCA2, HNPCC

    Molekulargewicht
    85kDa
    Gen-ID
    4292
    HGNC
    4292
    UniProt
    P40692
    Pathways
    DNA Reparatur, Production of Molecular Mediator of Immune Response
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