MUSK Antikörper (AA 24-209)

Produktnummer ABIN969299

Produktdetails anti-MUSK Antikörper

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Bindungsspezifität: AA 24-209

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUSK Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Verwendungszweck: MUSK Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.

Klon: 10A4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-MUSK Antikörper (ABIN969299)

Boneva, Frenkian-Cuvelier, Bidault, Brenner, Berrih-Aknin: "Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis." in: Journal of neuroimmunology, Vol. 177, Issue 1-2, pp. 119-31, (2006) (PubMed).

Details zu MUSK

Target: MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))

Andere Bezeichnung: MUSK (MUSK Produkte)

Hintergrund:

Description: MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

Aliases: muscle, skeletal, receptor tyrosine kinase

Molekulargewicht: 97kDa

Gen-ID: 4593

HGNC: 4593

UniProt: O15146

Pathways: RTK Signalweg, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development