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MUSK Antikörper (AA 24-209)

MUSK Reaktivität: Human ELISA, IHC, ICC Wirt: Maus Monoclonal 10A4 unconjugated
Produktnummer ABIN969299
  • Target Alle MUSK Antikörper anzeigen
    MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
    Bindungsspezifität
    • 15
    • 10
    • 8
    • 8
    • 7
    • 6
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 24-209
    Reaktivität
    • 72
    • 29
    • 25
    • 5
    • 5
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 67
    • 7
    • 2
    Maus
    Klonalität
    • 72
    • 7
    Monoklonal
    Konjugat
    • 39
    • 5
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MUSK Antikörper ist unkonjugiert
    Applikation
    • 67
    • 34
    • 29
    • 14
    • 13
    • 13
    • 11
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)
    Verwendungszweck
    MUSK Antibody
    Aufreinigung
    Ascitic fluid
    Immunogen
    Purified recombinant extracellular fragment of human MUSK (aa24-209) fused with hIgGFc tag expressed in HEK293 cell line.
    Klon
    10A4
    Isotyp
    IgG1
    Top Product
    Discover our top product MUSK Primärantikörper
  • Applikationshinweise

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Boneva, Frenkian-Cuvelier, Bidault, Brenner, Berrih-Aknin: "Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis." in: Journal of neuroimmunology, Vol. 177, Issue 1-2, pp. 119-31, (2006) (PubMed).

  • Target
    MUSK (Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK))
    Andere Bezeichnung
    MUSK (MUSK Produkte)
    Synonyme
    unp antikoerper, fj98e12 antikoerper, zgc:63467 antikoerper, wu:fj98e12 antikoerper, si:dz46m7.2 antikoerper, si:dz57f23.3 antikoerper, si:busm1-57f23.3 antikoerper, musk-A antikoerper, MuSK antikoerper, MUSK antikoerper, Mdk4 antikoerper, Mlk antikoerper, Nsk1 antikoerper, Nsk2 antikoerper, Nsk3 antikoerper, muscle antikoerper, muscle associated receptor tyrosine kinase antikoerper, muscle, skeletal, receptor tyrosine kinase antikoerper, muscle associated receptor tyrosine kinase S homeolog antikoerper, MUSK antikoerper, musk antikoerper, musk.S antikoerper, Musk antikoerper
    Hintergrund

    Description: MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.

    Aliases: muscle, skeletal, receptor tyrosine kinase

    Molekulargewicht
    97kDa
    Gen-ID
    4593
    HGNC
    4593
    UniProt
    O15146
    Pathways
    RTK Signalweg, Regulation of Muscle Cell Differentiation, Synaptic Membrane, Regulation of Cell Size, Skeletal Muscle Fiber Development
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