NQO1 Antikörper

Produktnummer ABIN969319

Produktdetails anti-NQO1 Antikörper

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser NQO1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Verwendungszweck: NQO1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human NQO1 expressed in E. Coli.

Klon: 4D12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-NQO1 Antikörper (ABIN969319)

Kansanen, Jyrkkänen, Volger, Leinonen, Kivelä, Häkkinen, Woodcock, Schopfer, Horrevoets, Ylä-Herttuala, Freeman, Levonen: "Nrf2-dependent and -independent responses to nitro-fatty acids in human endothelial cells: identification of heat shock response as the major pathway activated by nitro-oleic acid." in: The Journal of biological chemistry, Vol. 284, Issue 48, pp. 33233-41, (2009) (PubMed).

Douglas, Lim, Porter, West, Pink, Ge, Wylie, Tibbits, Biggs, Curtis, Palombella, Adams, Fritz, Normant: "The antiproliferative activity of the heat shock protein 90 inhibitor IPI-504 is not dependent on NAD(P)H:quinone oxidoreductase 1 activity in vivo." in: Molecular cancer therapeutics, Vol. 8, Issue 12, pp. 3369-78, (2009) (PubMed).

Details zu NQO1

Target: NQO1 (NAD(P)H Dehydrogenase, Quinone 1 (NQO1))

Andere Bezeichnung: NQO1 (NQO1 Produkte)

Hintergrund:

Description: This gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Aliases: DTD, QR1, DHQU, DIA4, NMOR1, NMORI

Molekulargewicht: 31kDa

Gen-ID: 1728

HGNC: 1728

UniProt: P15559