PDGFRB Antikörper
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- Target Alle PDGFRB Antikörper anzeigen
- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
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Reaktivität
- Human, Maus
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser PDGFRB Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of human PDGFRbeta expressed in E. coli.
- Klon
- 1A2
- Isotyp
- IgG1
- Top Product
- Discover our top product PDGFRB Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells." in: Journal of virology, Vol. 81, Issue 10, pp. 5112-20, (2007) (PubMed).
: "Expression and mutational analysis of tyrosine kinase receptors c-kit, PDGFRalpha, and PDGFRbeta in ovarian cancers." in: Human pathology, Vol. 36, Issue 3, pp. 242-9, (2005) (PubMed).
: "Association of coatomer proteins with the beta-receptor for platelet-derived growth factor." in: Biochemical and biophysical research communications, Vol. 235, Issue 3, pp. 455-60, (1997) (PubMed).
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Human cytomegalovirus downregulates expression of receptors for platelet-derived growth factor by smooth muscle cells." in: Journal of virology, Vol. 81, Issue 10, pp. 5112-20, (2007) (PubMed).
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- Target
- PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))
- Andere Bezeichnung
- PDGFRbeta (PDGFRB Produkte)
- Synonyme
- AI528809 antikoerper, CD140b antikoerper, PDGFR-1 antikoerper, Pdgfr antikoerper, CD140B antikoerper, IBGC4 antikoerper, JTK12 antikoerper, PDGFR antikoerper, PDGFR1 antikoerper, platelet derived growth factor receptor, beta polypeptide antikoerper, platelet derived growth factor receptor beta antikoerper, Pdgfrb antikoerper, PDGFRB antikoerper
- Hintergrund
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Description: Platelet-derived growth factor receptor, beta polypeptide, also known as PDGFRB, PDGFRβ or CD140B. It is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. This family exist as several disulphide-bonded, dimeric isoforms (PDGF AA, PDGF AB, PDGF BB, PDGF CC and PDGF DD) that bind in a specific pattern to two closely related receptor tyrosine kinases, PDGF receptor α (PDGFRα) and PDGF receptor β (PDGFRβ). These growth factors are mitogens for cells of mesenchymal origin. PDGFRB is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor, all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the translocation, ETV6, leukemia gene, results in chronic myeloproliferative disorder with eosinophilia.
Aliases: JTK12, PDGFR, CD140B, PDGFR1, PDGFRB
- Molekulargewicht
- 190 kDa
- Gen-ID
- 5159
- HGNC
- 5159
- Pathways
- Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling
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