RSPO1 Antikörper
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- Target Alle RSPO1 Antikörper anzeigen
- RSPO1 (R-Spondin 1 (RSPO1))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser RSPO1 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA
- Aufreinigung
- purified
- Immunogen
- Purified recombinant fragment of R-spondin1 expressed in E. coli.
- Klon
- 7A6
- Isotyp
- IgG1
- Top Product
- Discover our top product RSPO1 Primärantikörper
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- Applikationshinweise
- ELISA: 1:10000, WB: 1:500 - 1:2000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Ascitic fluid containing 0.03 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- 4°C, -20°C for long term storage
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Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).
: "R-spondin1 is essential in sex determination, skin differentiation and malignancy." in: Nature genetics, Vol. 38, Issue 11, pp. 1304-9, (2006) (PubMed).
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Syndromic true hermaphroditism due to an R-spondin1 (RSPO1) homozygous mutation." in: Human mutation, Vol. 29, Issue 2, pp. 220-6, (2008) (PubMed).
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- Target
- RSPO1 (R-Spondin 1 (RSPO1))
- Andere Bezeichnung
- R-spondin1 (RSPO1 Produkte)
- Synonyme
- RGD1565558 antikoerper, CRISTIN3 antikoerper, RSPO antikoerper, R-spondin antikoerper, Rspondin antikoerper, wu:fj81e05 antikoerper, zgc:92153 antikoerper, R-spondin 1 antikoerper, Rspo1 antikoerper, RSPO1 antikoerper, LOC100049655 antikoerper, rspo1 antikoerper
- Hintergrund
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Description: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1. It is a member of the R-spondin family and a 28.9 kDa secreted activator protein with two cystein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects.It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
Aliases: RSPO1,CRISTIN3,FLJ40906
- Molekulargewicht
- 28.9 kDa
- Gen-ID
- 284654
- HGNC
- 284654
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