RAG2 Antikörper (AA 350-527)

Produktnummer ABIN969379

Produktdetails anti-RAG2 Antikörper

Target: RAG2 (Recombination Activating Gene 2 (RAG2))

Bindungsspezifität: AA 350-527

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser RAG2 Antikörper ist unkonjugiert

Applikation: ELISA

Verwendungszweck: RAG2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human RAG2(350-527aa) expressed in E. Coli.

Klon: 4D5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-RAG2 Antikörper (ABIN969379)

Nagawa, Hirose, Nishizumi, Nishihara, Sakano: "Joining mutants of RAG1 and RAG2 that demonstrate impaired interactions with the coding-end DNA." in: The Journal of biological chemistry, Vol. 279, Issue 37, pp. 38360-8, (2004) (PubMed).

Details zu RAG2

Target: RAG2 (Recombination Activating Gene 2 (RAG2))

Andere Bezeichnung: RAG2 (RAG2 Produkte)

Synonyme: RAG-2 antikoerper, Rag-2 antikoerper, rag-2 antikoerper, zgc:136743 antikoerper, recombination activating 2 antikoerper, recombination activating gene 2 antikoerper, recombination activating gene 2 S homeolog antikoerper, RAG2 antikoerper, Rag2 antikoerper, rag2 antikoerper, rag2.S antikoerper

Hintergrund:

Description: This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Aliases: RAG-2, RAG2

Molekulargewicht: 59kDa

Gen-ID: 5897

HGNC: 5897

UniProt: P55895

Pathways: Chromatin Binding, Production of Molecular Mediator of Immune Response