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RICTOR Antikörper

RICTOR Reaktivität: Human, Maus, Affe WB, IHC, ELISA, ICC, FACS Wirt: Maus Monoclonal 7B3 unconjugated
Produktnummer ABIN969382
  • Target Alle RICTOR Antikörper anzeigen
    RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))
    Reaktivität
    • 57
    • 31
    • 3
    • 1
    • 1
    Human, Maus, Affe
    Wirt
    • 52
    • 5
    • 1
    Maus
    Klonalität
    • 52
    • 6
    Monoklonal
    Konjugat
    • 37
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser RICTOR Antikörper ist unkonjugiert
    Applikation
    • 43
    • 31
    • 20
    • 10
    • 8
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human RICTOR expressed in E. coli.
    Klon
    7B3
    Isotyp
    IgG1
    Top Product
    Discover our top product RICTOR Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Yang, Inoki, Ikenoue, Guan: "Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity." in: Genes & development, Vol. 20, Issue 20, pp. 2820-32, (2006) (PubMed).

  • Target
    RICTOR (RPTOR Independent Companion of mTOR, Complex 2 (RICTOR))
    Andere Bezeichnung
    RICTOR (RICTOR Produkte)
    Synonyme
    PIA antikoerper, mAVO3 antikoerper, 4921505C17Rik antikoerper, 6030405M08Rik antikoerper, AVO3 antikoerper, AW492497 antikoerper, D530039E11Rik antikoerper, Fyb antikoerper, RPTOR independent companion of MTOR complex 2 antikoerper, RPTOR independent companion of MTOR, complex 2 antikoerper, RICTOR antikoerper, Rictor antikoerper
    Hintergrund

    Description: Cell growth is a fundamental biological process whereby cells accumulate mass and increase in size. The mammalian TOR (mTOR) pathway regulates growth by coordinating energy and nutrient signals with growth factor-derived signals . mTOR is a large protein kinase with two different complexes. One complex contains mTOR, GβL and raptor, which is a target of rapamycin. The other complex, insensitive to rapamycin, includes mTOR, GβL, Sin1 and rictor . The mTOR-rictor complex phosphorylates Ser473 of Akt/PKB in vitro . This phosphorylation is essential for full Akt/PKB activation. Furthermore, an siRNA knockdown of rictor inhibits Ser473 phosphorylation in 3T3-L1 adipocytes . This complex has also been shown to phosphorylate the rapamycin-resistant mutants of S6K1, another effector of mTOR .

    Aliases: PIA, mAVO3, KIAA1999, MGC39830, DKFZp686B11164, RICTOR

    Molekulargewicht
    192 kDa
    Gen-ID
    253260
    HGNC
    253260
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of Actin Filament Polymerization, CXCR4-mediated Signaling Events
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