SNAIL Antikörper

Produktnummer ABIN969409

Produktdetails anti-SNAIL Antikörper

Target: SNAIL (SNAI1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SNAIL Antikörper ist unkonjugiert

Applikation: ELISA

Verwendungszweck: SNAI1 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human SNAI1 expressed in E. Coli.

Klon: 6D2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-SNAIL Antikörper (ABIN969409)

Wanami, Chen, Peiró, García de Herreros, Bachelder: "Vascular endothelial growth factor-A stimulates Snail expression in breast tumor cells: implications for tumor progression." in: Experimental cell research, Vol. 314, Issue 13, pp. 2448-53, (2008) (PubMed).

Herranz, Pasini, Díaz, Francí, Gutierrez, Dave, Escrivà, Hernandez-Muñoz, Di Croce, Helin, García de Herreros, Peiró: "Polycomb complex 2 is required for E-cadherin repression by the Snail1 transcription factor." in: Molecular and cellular biology, Vol. 28, Issue 15, pp. 4772-81, (2008) (PubMed).

Details zu SNAIL

Target: SNAIL (SNAI1)

Andere Bezeichnung: SNAI1 (SNAI1 Produkte)

Synonyme: SLUGH2 antikoerper, SNA antikoerper, SNAH antikoerper, SNAIL antikoerper, SNAIL1 antikoerper, dJ710H13.1 antikoerper, AI194338 antikoerper, Sna antikoerper, Sna1 antikoerper, Snail antikoerper, Snail1 antikoerper, SNAI1 antikoerper, BG:DS01845.1 antikoerper, CG3956 antikoerper, Dmel\\CG3956 antikoerper, Sco antikoerper, br28 antikoerper, br29 antikoerper, l(2)35Db antikoerper, l(2)br28 antikoerper, l(2)br29 antikoerper, l(3)br28 antikoerper, l35Db antikoerper, sn antikoerper, Xsnail antikoerper, sna antikoerper, snail1 antikoerper, xSna antikoerper, Snai antikoerper, sna2 antikoerper, snail2 antikoerper, cb643 antikoerper, sna-1 antikoerper, sna1 antikoerper, snai1 antikoerper, snail1a antikoerper, zgc:109820 antikoerper, snail family transcriptional repressor 1 antikoerper, snail family zinc finger 1 antikoerper, snail homolog 1 (Drosophila) antikoerper, snail antikoerper, zinc-finger transcription factor Snail antikoerper, snail family zinc finger 1 S homeolog antikoerper, protein escargot antikoerper, transcription factor protein antikoerper, snail zinc finger protein antikoerper, snail family zinc finger 1b antikoerper, snail family zinc finger 1a antikoerper, SNAI1 antikoerper, Snai1 antikoerper, sna antikoerper, snail antikoerper, snai1.S antikoerper, LOC410464 antikoerper, snai1b antikoerper, snai1a antikoerper

Hintergrund:

Description: Snail is a zinc-finger transcription factor that can repress E-cadherin transcription. Downregulation of E-cadherin is associated with epithelial-mesenchymal transition during embryonic development, a process also exploited by invasive cancer cells . Indeed, loss of E-cadherin expression is correlated with the invasive properties of some tumors and there is a considerable inverse correlation between Snail and E-cadherin mRNA levels in epithelial tumor cell lines . In addition, Snail blocks the cell cycle and confers resistance to cell death . Phosphorylation of Snail by GSK-3 and PAK1 regulates its stability, cellular localization and function .Tissue specificity: Expressed in a variety of tissues with the highest expression in kidney.

Aliases: SNA, SNAH, SLUGH2, dJ710H13.1, SNAI1

Molekulargewicht: 29kDa

Gen-ID: 6615

HGNC: 6615

UniProt: O95863

Pathways: Negative Regulation of intrinsic apoptotic Signaling