SLUG Antikörper

Produktnummer ABIN969410

Produktdetails anti-SLUG Antikörper

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SLUG Antikörper ist unkonjugiert

Applikation: ELISA

Verwendungszweck: SNAI2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human SNAI2 expressed in E. Coli.

Klon: 2H5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-SLUG Antikörper (ABIN969410)

Saegusa, Hashimura, Kuwata, Okayasu: "Requirement of the Akt/beta-catenin pathway for uterine carcinosarcoma genesis, modulating E-cadherin expression through the transactivation of slug." in: The American journal of pathology, Vol. 174, Issue 6, pp. 2107-15, (2009) (PubMed).

Medici, Hay, Olsen: "Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3." in: Molecular biology of the cell, Vol. 19, Issue 11, pp. 4875-87, (2008) (PubMed).

Details zu SLUG

Target: SLUG (SNAI2) (Snail Family Zinc Finger 2 (SNAI2))

Andere Bezeichnung: SNAI2 (SNAI2 Produkte)

Hintergrund:

Description: This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity.The tumor suppressor protein p53 induces Slug expression in -irradiated cells, Slug protects damaged cells from apoptosis by repressing p53-induced transcription of the proapoptotic Bcl-2 family protein Puma. Mutations in this gene may be associated with sporatic cases of neural tube defects.

Aliases: SLUG, WS2D, SLUGH1, MGC10182, SNAI2

Molekulargewicht: 30kDa

Gen-ID: 6591

HGNC: 6591

UniProt: O43623