TNNI2 Antikörper

Produktnummer ABIN969441

Produktdetails anti-TNNI2 Antikörper

Target: TNNI2 (Fast Skeletal Troponin I (TNNI2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNNI2 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Verwendungszweck: TNNI2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human TNNI2 expressed in E. Coli.

Klon: 2F12A11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-TNNI2 Antikörper (ABIN969441)

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Moran, Garriock, Miller, Heimark, Gregorio, Krieg: "Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle." in: Cell motility and the cytoskeleton, Vol. 65, Issue 8, pp. 652-61, (2008) (PubMed).

Details zu TNNI2

Target: TNNI2 (Fast Skeletal Troponin I (TNNI2))

Andere Bezeichnung: TNNI2 (TNNI2 Produkte)

Synonyme: AMCD2B antikoerper, DA2B antikoerper, FSSV antikoerper, fsTnI antikoerper, TnI-F4 antikoerper, TnI antikoerper, TNI antikoerper, hm:zehn0173 antikoerper, tnni2 antikoerper, tropI-1d antikoerper, zgc:86800 antikoerper, troponin I2, fast skeletal type antikoerper, troponin I type 2 (skeletal, fast) antikoerper, troponin I, fast skeletal muscle-like antikoerper, troponin I, skeletal, fast 2 antikoerper, troponin I type 2a (skeletal, fast), tandem duplicate 4 antikoerper, TNNI2 antikoerper, Tnni2 antikoerper, tnni2a.4 antikoerper

Hintergrund:

Description: This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene.

Aliases: DA2B, FSSV, fsTnI, AMCD2B

Molekulargewicht: 21kDa

Gen-ID: 7136

HGNC: 7136

UniProt: P48788