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TRIM5 Antikörper

TRIM5 Reaktivität: Human WB, ELISA, IHC Wirt: Maus Monoclonal 3B11H2 unconjugated
Produktnummer ABIN969443
  • Target Alle TRIM5 Antikörper anzeigen
    TRIM5 (Tripartite Motif Containing 5 (TRIM5))
    Reaktivität
    • 38
    • 4
    • 2
    • 1
    • 1
    Human
    Wirt
    • 34
    • 3
    • 1
    Maus
    Klonalität
    • 35
    • 3
    Monoklonal
    Konjugat
    • 29
    • 3
    • 2
    • 2
    • 1
    • 1
    Dieser TRIM5 Antikörper ist unkonjugiert
    Applikation
    • 32
    • 21
    • 9
    • 8
    • 4
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Verwendungszweck
    Trim5a Antibody
    Aufreinigung
    Ascitic fluid
    Immunogen
    Purified recombinant fragment of human trim5 alpha expressed in E. Coli.
    Klon
    3B11H2
    Isotyp
    IgG1
    Top Product
    Discover our top product TRIM5 Primärantikörper
  • Applikationshinweise
    ELISA: 1/10000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Ascitic fluid containing 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Song, Javanbakht, Perron, Park, Stremlau, Sodroski: "Retrovirus restriction by TRIM5alpha variants from Old World and New World primates." in: Journal of virology, Vol. 79, Issue 7, pp. 3930-7, (2005) (PubMed).

    Keckesova, Ylinen, Towers: "The human and African green monkey TRIM5alpha genes encode Ref1 and Lv1 retroviral restriction factor activities." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 29, pp. 10780-5, (2004) (PubMed).

    Stremlau, Owens, Perron, Kiessling, Autissier, Sodroski: "The cytoplasmic body component TRIM5alpha restricts HIV-1 infection in Old World monkeys." in: Nature, Vol. 427, Issue 6977, pp. 848-53, (2004) (PubMed).

  • Target
    TRIM5 (Tripartite Motif Containing 5 (TRIM5))
    Andere Bezeichnung
    Trim5a (TRIM5 Produkte)
    Hintergrund

    Description: TRIM5-alpha is a protein that is found in the cells of many mammals and fends of various retrovirus infections. It protects monkeys from infection with HIV-1, and humans from infection with some other viruses. If a retrovirus has entered a cell, it needs to shed its capsid in order to reversely transcribe its genes, so that they can be expressed by the host cell. It is believed that TRIM5 alpha, which is present in the cytoplasm, somehow recognizes the capsid and blocks its shedding, thereby stopping the virus in its tracks. It thus represents an intracellular defense completely separate from the rest of the body's immune system.

    Aliases: RNF88, TRIM5alpha

    Gen-ID
    85363
    HGNC
    85364
    UniProt
    Q9C035
    Pathways
    Activation of Innate immune Response
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