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MTDH Antikörper

MTDH Reaktivität: Human WB, IHC, ELISA, FACS Wirt: Maus Monoclonal 2F11C3 unconjugated
Produktnummer ABIN969496
  • Target Alle MTDH Antikörper anzeigen
    MTDH (Metadherin (MTDH))
    Reaktivität
    • 49
    • 18
    • 7
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 41
    • 6
    • 3
    Maus
    Klonalität
    • 46
    • 4
    Monoklonal
    Konjugat
    • 28
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser MTDH Antikörper ist unkonjugiert
    Applikation
    • 40
    • 14
    • 13
    • 13
    • 10
    • 9
    • 9
    • 8
    • 7
    • 4
    • 3
    • 2
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS)
    Aufreinigung
    purified
    Immunogen
    Purified recombinant fragment of human Metadherin expressed in E. coli.
    Klon
    2F11C3
    Isotyp
    IgG1
    Top Product
    Discover our top product MTDH Primärantikörper
  • Applikationshinweise
    ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, FCM: 1:200 - 1:400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Antibody are purified by protein G affinity chromatography. Liquid in PBS containing 50 % glycerol and 0.03 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-20 °C
    Informationen zur Lagerung
    4°C, -20°C for long term storage
  • Britt, Yang, Yang, Flanagan, Callanan, Lim, Lin, Hixson: "Identification of a novel protein, LYRIC, localized to tight junctions of polarized epithelial cells." in: Experimental cell research, Vol. 300, Issue 1, pp. 134-48, (2004) (PubMed).

    Brown, Ruoslahti: "Metadherin, a cell surface protein in breast tumors that mediates lung metastasis." in: Cancer cell, Vol. 5, Issue 4, pp. 365-74, (2004) (PubMed).

  • Target
    MTDH (Metadherin (MTDH))
    Andere Bezeichnung
    Metadherin (MTDH Produkte)
    Synonyme
    MGC75963 antikoerper, 2610103J23Rik antikoerper, 3D3 antikoerper, 3D3/Lyric antikoerper, AEG-1 antikoerper, AV353288 antikoerper, D8Bwg1112e antikoerper, Lyric antikoerper, AEG1 antikoerper, LYRIC antikoerper, LYRIC/3D3 antikoerper, metadherin antikoerper, mtdh antikoerper, MTDH antikoerper, Mtdh antikoerper
    Hintergrund

    Description: Metadherin (Metastasis adhesion protein), also known as MTDH, LYsine-RIch CEACAM1 co-isolated (LYRIC), is a novel protein that localizes with the tight junction proteins ZO-1 and occludin in polarized epithelial cells. At the tight junction, it acts not as a structural component, but is rather recruited during the maturation of the tight junction complex. Metadherin is overexpressed in breast cancer tissue and breast tumor xenografts, while much lower levels are expressed in normal breast tissue. Metadherin binds to lung vasculature, one of the four common sites of breast cancer metastasis, through a C-terminal segment in the extracellular domain, blocking this lung-homing domain with antibodies or inhibiting metadherin with siRNA has been reported to inhibit breast cancer metastasis.

    Aliases: 3D3, AEG1, LYRIC, MTDH

    Molekulargewicht
    64 kDa
    Gen-ID
    92140
    HGNC
    92140
    Pathways
    Cellular Response to Molecule of Bacterial Origin, Cell-Cell Junction Organization
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