Lp(a) Antikörper (AA 1823-2013)

Produktnummer ABIN969533

Produktdetails anti-Lp(a) Antikörper

Target: Lp(a) (Lipoprotein (Lp(a)))

Bindungsspezifität: AA 1823-2013

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Lp(a) Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Verwendungszweck: LPA Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human LPA (AA: 1823-2013) expressed in E. Coli.

Klon: 4H1

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Lp(a) Antikörper (ABIN969533)

Nicholls, Tang, Scoffone, Brennan, Hartiala, Allayee, Hazen: "Lipoprotein(a) levels and long-term cardiovascular risk in the contemporary era of statin therapy." in: Journal of lipid research, Vol. 51, Issue 10, pp. 3055-61, (2010) (PubMed).

Rodger, Le Gal, Carrier, Betancourt, Kahn, Wells, Anderson, Lacut, Chagnon, Solymoss, Crowther, Perrier, White, Vickars, Ramsay, Kovacs: "Serum lipoprotein (a) levels in patients with first unprovoked venous thromboembolism is not associated with subsequent risk of recurrent VTE." in: Thrombosis research, Vol. 126, Issue 3, pp. 222-6, (2010) (PubMed).

Details zu Lp(a)

Target: Lp(a) (Lipoprotein (Lp(a)))

Andere Bezeichnung: LPA

Hintergrund:

Description: The protein encoded by this gene is a serine proteinase that inhibits the activity of tissue-type plasminogen activator I. The encoded protein constitutes a substantial portion of lipoprotein(a) and is proteolytically cleaved, resulting in fragments that attach to atherosclerotic lesions and promote thrombogenesis. Elevated plasma levels of this protein are linked to atherosclerosis. Depending on the individual, the encoded protein contains 2-43 copies of kringle-type domains. The allele represented here contains 15 copies of the kringle-type repeats and corresponds to that found in the reference genome sequence.

Aliases: LP, AK38, APOA

Molekulargewicht: 501kDa

Gen-ID: 4018

HGNC: 4018

UniProt: P08519