LRP5 Antikörper

Produktnummer ABIN969535

Produktdetails anti-LRP5 Antikörper

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LRP5 Antikörper ist unkonjugiert

Applikation: ELISA, Flow Cytometry (FACS)

Verwendungszweck: LRP5 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human LRP5 expressed in E. Coli.

Klon: 2B11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-LRP5 Antikörper (ABIN969535)

Saarinen, Mäyränpää, Lehesjoki, Mäkitie: "Low-density lipoprotein receptor-related protein 5 (LRP5) variation in fracture prone children." in: Bone, Vol. 46, Issue 4, pp. 940-5, (2010) (PubMed).

Urano, Shiraki, Usui, Sasaki, Ouchi, Inoue: "A1330V variant of the low-density lipoprotein receptor-related protein 5 (LRP5) gene decreases Wnt signaling and affects the total body bone mineral density in Japanese women." in: Endocrine journal, Vol. 56, Issue 4, pp. 625-31, (2009) (PubMed).

Details zu LRP5

Target: LRP5 (Low Density Lipoprotein Receptor-Related Protein 5 (LRP5))

Andere Bezeichnung: LRP5 (LRP5 Produkte)

Hintergrund:

Description: This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy.

Aliases: HBM, LR3, OPS, EVR1, EVR4, LRP7, OPPG, BMND1, OPTA1, VBCH2

Molekulargewicht: 179kDa

Gen-ID: 4041

HGNC: 4041

UniProt: O75197

Pathways: WNT Signalweg, Stem Cell Maintenance, Positive Regulation of fat Cell Differentiation