PAX5 Antikörper (AA 235-382)

Produktnummer ABIN969552

Produktdetails anti-PAX5 Antikörper

Target: PAX5 (Paired Box 5 (PAX5))

Bindungsspezifität: AA 235-382

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PAX5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Verwendungszweck: PAX5 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human PAX5 (AA: 235-382) expressed in E. Coli.

Klon: 1A7

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-PAX5 Antikörper (ABIN969552)

Coyaud, Struski, Prade, Familiades, Eichner, Quelen, Bousquet, Mugneret, Talmant, Pages, Lefebvre, Penther, Lippert, Nadal, Taviaux, Poppe, Luquet, Baranger, Eclache, Radford, Barin, Mozziconacci et al.: "Wide diversity of PAX5 alterations in B-ALL: a Groupe Francophone de Cytogenetique Hematologique study. ..." in: Blood, Vol. 115, Issue 15, pp. 3089-97, (2010) (PubMed).

Arseneau, Laflamme, Lewis, Maïcas, Ouellette: "Multiple isoforms of PAX5 are expressed in both lymphomas and normal B-cells." in: British journal of haematology, Vol. 147, Issue 3, pp. 328-38, (2009) (PubMed).

Details zu PAX5

Target: PAX5 (Paired Box 5 (PAX5))

Andere Bezeichnung: PAX5 (PAX5 Produkte)

Hintergrund:

Description: This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9,14)(p13,q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Aliases: BSAP

Molekulargewicht: 45kDa

Gen-ID: 5079

HGNC: 5079

UniProt: Q02548