PPP2R4 Antikörper

Produktnummer ABIN969557

Produktdetails anti-PPP2R4 Antikörper

Target: PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PPP2R4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Verwendungszweck: PPP2R4 Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human PPP2R4 expressed in E. Coli.

Klon: 4D9

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/200 - 1/1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-PPP2R4 Antikörper (ABIN969557)

Yoon, Jun, Park, Jun Yoo, Moon, Soon Baik, Kim, Kim, Kim, Koh, Taek Lee, You: "Optimal suppression of protein phosphatase 2A activity is critical for maintenance of human embryonic stem cell self-renewal." in: Stem cells (Dayton, Ohio), Vol. 28, Issue 5, pp. 874-84, (2010) (PubMed).

Singh, Ye, Bucur, Zhu, Tanya Santos, Rabinovitz, Wei, Gao, Hahn, Khosravi-Far: "Protein phosphatase 2A reactivates FOXO3a through a dynamic interplay with 14-3-3 and AKT." in: Molecular biology of the cell, Vol. 21, Issue 6, pp. 1140-52, (2010) (PubMed).

Details zu PPP2R4

Target: PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))

Andere Bezeichnung: PPP2R4 (PPP2R4 Produkte)

Synonyme: PP2A antikoerper, PR53 antikoerper, PTPA antikoerper, 2610042B21Rik antikoerper, C77440 antikoerper, N28142 antikoerper, PTPRA antikoerper, Ppp2r4 antikoerper, fc23d07 antikoerper, ppp2r4 antikoerper, wu:fc23d07 antikoerper, zgc:92766 antikoerper, pp2a antikoerper, ppp2r4.L antikoerper, pr53 antikoerper, ptpa antikoerper, protein phosphatase 2 phosphatase activator antikoerper, protein phosphatase 2 protein activator antikoerper, protein phosphatase 2 phosphatase activator L homeolog antikoerper, PTPA antikoerper, Ptpa antikoerper, ptpa antikoerper, ptpa.L antikoerper

Hintergrund:

Description: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

Aliases: PP2A, PR53, PTPA

Molekulargewicht: 41kDa

Gen-ID: 5524

HGNC: 5524

UniProt: Q15257

Pathways: PI3K-Akt Signalweg, M Phase, Hepatitis C, Toll-Like Receptors Cascades