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APOBEC3A Produkte

(Apolipoprotein B mRNA Editing Enzyme, Catalytic Polypeptide-Like 3A (APOBEC3A))

Kategorien

This gene is a member of the cytidine deaminase gene family. It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1. The protein encoded by this gene lacks the zinc binding activity of other family members. The protein plays a role in immunity, by restricting transmission of foreign DNA such as viruses. One mechanism of foreign DNA restriction is deamination of foreign double-stranded DNA cytidines to uridines, which leads to DNA degradation. However, other mechanisms are also thought to be involved, as anti-viral effect is not dependent on deaminase activity. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2012].

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Ausgewählte APOBEC3A Kategorien

APOBEC3A Antikörper

High quality antibodies with extensive validation data.

Empfohlene APOBEC3A Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, WB, IHC, IF, FACS
Validierungen
  • (4)
Kat. Nr. ABIN238645
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB
Validierungen
  • (5)
  • (1)
Kat. Nr. ABIN1881066
Menge 400 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse
Applikation ELISA, WB, IF, ICC
Validierungen
  • (2)
Kat. Nr. ABIN6259984
Menge 100 μL
Datenblatt Datenblatt

Empfohlene APOBEC3A Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Tobacco (Nicotiana tabacum)
Validierungen
Kat. Nr. ABIN3087958
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN2714811
Menge 20 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren APOBEC3A Produkten

Zahoor, Xue, Sato, Murakami, Takeshima, Aida: "HIV-1 Vpr induces interferon-stimulated genes in human monocyte-derived macrophages." in: PLoS ONE, Vol. 9, Issue 8, pp. e106418, (2014) (PubMed).

Thielen, McNevin, McElrath, Hunt, Klein, Lingappa: "Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms." in: The Journal of biological chemistry, Vol. 285, Issue 36, pp. 27753-66, (2010) (PubMed).

Berger, Münk, Schweizer, Cichutek, Schüle, Flory: "Interaction of Vpx and apolipoprotein B mRNA-editing catalytic polypeptide 3 family member A (APOBEC3A) correlates with efficient lentivirus infection of monocytes." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12248-54, (2010) (PubMed).

Stenglein, Burns, Li, Lengyel, Harris: "APOBEC3 proteins mediate the clearance of foreign DNA from human cells." in: Nature structural & molecular biology, Vol. 17, Issue 2, pp. 222-9, (2010) (PubMed).

Abe, Ochi, Maekawa, Hatakeyama, Tsuge, Kitamura, Kimura, Miki, Mitsui, Hiraga, Imamura, Fujimoto, Takahashi, Nakamura, Kumada, Chayama: "Effects of structural variations of APOBEC3A and APOBEC3B genes in chronic hepatitis B virus infection." in: Hepatology research : the official journal of the Japan Society of Hepatology, Vol. 39, Issue 12, pp. 1159-68, (2009) (PubMed).

Prochnow, Bransteitter, Chen: "APOBEC deaminases-mutases with defensive roles for immunity." in: Science in China. Series C, Life sciences / Chinese Academy of Sciences, Vol. 52, Issue 10, pp. 893-902, (2009) (PubMed).

Goila-Gaur, Khan, Miyagi, Kao, Strebel: "Targeting APOBEC3A to the viral nucleoprotein complex confers antiviral activity." in: Retrovirology, Vol. 4, pp. 61, (2007) (PubMed).

Wedekind, Dance, Sowden, Smith: "Messenger RNA editing in mammals: new members of the APOBEC family seeking roles in the family business." in: Trends in genetics : TIG, Vol. 19, Issue 4, pp. 207-16, (2003) (PubMed).

Jarmuz, Chester, Bayliss, Gisbourne, Dunham, Scott, Navaratnam: "An anthropoid-specific locus of orphan C to U RNA-editing enzymes on chromosome 22." in: Genomics, Vol. 79, Issue 3, pp. 285-96, (2002) (PubMed).

Synonyme und alternative Namen zu APOBEC3A

apolipoprotein B mRNA editing enzyme catalytic subunit 3A (APOBEC3A), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3Z1), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3Z1 (APOBEC3Z1), similar to ARP10 protein (APOBEC3A), apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A (APOBEC3A), A3A, APOBEC3A, APOBEC3Z1, ARP3, bK150C2.1, PHRBN

Bezeichner auf Proteinebene für APOBEC3A

  • DNA dC->dU-editing enzyme APOBEC-3A
  • phorbolin 1
  • phorbolin-1
  • probable DNA dC->dU-editing enzyme APOBEC-3A
  • apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
  • similar to ARP10 protein
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