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APPL2 Produkte

(Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 2 (APPL2))

Kategorien

The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12\;22)(q24.1\;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011].

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Ausgewählte APPL2 Kategorien

APPL2 Antikörper

High quality antibodies with extensive validation data.

APPL2 Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene APPL2 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation WB, ELISA, IF
Validierungen
  • (4)
Kat. Nr. ABIN527415
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation WB, IF
Validierungen
  • (1)
  • (3)
Kat. Nr. ABIN527414
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IF, IHC
Validierungen
  • (2)
Kat. Nr. ABIN7149505
Menge 100 μg
Datenblatt Datenblatt

Empfohlene APPL2 ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6964611
Menge 96 tests
Datenblatt Datenblatt

Empfohlene APPL2 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN7121696
Menge 50 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1345412
Menge 10 μg
Datenblatt Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN1345410
Menge 10 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren APPL2 Produkten

Gaspar, Muñoz, Kuga, Nakandakari, Crisol, Lenhare, Breda, Botezelli, SantAna, da Silva, Cintra, de Moura, Ropelle, Pauli: "Acute physical exercise increases APPL1/PI3K signaling in the hypothalamus of lean mice." in: The European journal of neuroscience, (2019) (PubMed).

Canciglieri, Kuga, Muñoz, Gaspar, da Rocha, Breda, Anaruma, Minuzzi, da Silva, Cintra, de Moura, Ropelle, Pauli: "The reversal effect of physical exercise on aging-related increases in APPL2 content in skeletal muscle." in: Life sciences, Vol. 210, pp. 209-213, (2018) (PubMed).

Gaspar, Muñoz, Formigari, Kuga, Nakandakari, Botezelli, da Silva, Cintra, de Moura, Ropelle, Pauli: "Acute physical exercise increases the adaptor protein APPL1 in the hypothalamus of obese mice." in: Cytokine, Vol. 110, pp. 87-93, (2018) (PubMed).

Cleasby, Lau, Polkinghorne, Patel, Leslie, Turner, Cooney, Xu, Kraegen: "The adaptor protein APPL1 increases glycogen accumulation in rat skeletal muscle through activation of the PI3-kinase signalling pathway." in: The Journal of endocrinology, Vol. 210, Issue 1, pp. 81-92, (2011) (PubMed).

Synonyme und alternative Namen zu APPL2

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (Appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (APPL2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 L homeolog (appl2.L), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (appl2), adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 (appl2), adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 (Appl2), APPL2, Dip3b, dip13b, DIP13B, MGC84621, RGD1563028

Bezeichner auf Proteinebene für APPL2

  • DCC-interacting protein 13-beta
  • adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2
  • amyloid beta (A4) precursor-like protein 2
  • DIP13 beta
  • adapter protein containing PH domain, PTB domain and leucine zipper motif 2
  • Dip3 beta
  • dip13-beta
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