Ataxin 2 Produkte
(Ataxin 2 (ATXN2))
Kategorien
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. This locus has been mapped to chromosome 12, and it has been determined that the diseased allele contains 37-50 CAG repeats, compared to 17-29 in the normal allele. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined. [provided by RefSeq, Jan 2010].
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Ausgewählte Ataxin 2 Kategorien
Ataxin 2 Antikörper
High quality antibodies with extensive validation data.
Ataxin 2 ELISA Kits
Reliable ELISA kits for a wide range of species.
Ataxin 2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene Ataxin 2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC, IF
Validierungen
- (5)
Kat. Nr.
ABIN7259314
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
WB, IF, ICC, FACS
Validierungen
- (7)
Kat. Nr.
ABIN3028477
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Mouse
Applikation
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validierungen
- (3)
Kat. Nr.
ABIN872411
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene Ataxin 2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN6962049
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Rat
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN1113614
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
Kat. Nr.
ABIN1113615
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene Ataxin 2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7121916
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346193
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
Kat. Nr.
ABIN7505038
Menge
100 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren Ataxin 2 Produkten
: "Intersection of calorie restriction and magnesium in the suppression of genome-destabilizing RNA-DNA hybrids." in: Nucleic acids research, Vol. 44, Issue 18, pp. 8870-8884, (2016) (PubMed).: "Generation of human-induced pluripotent stem cells to model spinocerebellar ataxia type 2 in vitro." in: Journal of molecular neuroscience : MN, Vol. 51, Issue 2, pp. 237-48, (2013) (PubMed).
: "Ataxin-2-like is a regulator of stress granules and processing bodies." in: PLoS ONE, Vol. 7, Issue 11, pp. e50134, (2012) (PubMed).
: "Multiple common variants for celiac disease influencing immune gene expression. ..." in: Nature genetics, Vol. 42, Issue 4, pp. 295-302, (2010) (PubMed).
: "Expression of ataxin-2 in brains from normal individuals and patients with Alzheimer's disease and spinocerebellar ataxia 2." in: Annals of neurology, Vol. 45, Issue 2, pp. 232-41, (1999) (PubMed).
: "The mouse SCA2 gene: cDNA sequence, alternative splicing and protein expression." in: Human molecular genetics, Vol. 7, Issue 8, pp. 1301-9, (1998) (PubMed).
: "Moderate expansion of a normally biallelic trinucleotide repeat in spinocerebellar ataxia type 2." in: Nature genetics, Vol. 14, Issue 3, pp. 269-76, (1996) (PubMed).
Synonyme und alternative Namen zu Ataxin 2
ataxin 2 (ATXN2), ataxin 2 (Atxn2), ataxin 2 L homeolog (atxn2.L), 9630045M23Rik, ASL13, ATX2, ATXN2, AW544490, MGC115230, SCA2, Sca2, TNRC13Bezeichner auf Proteinebene für Ataxin 2
- ataxin-2
- spinocerebellar ataxia type 2 protein
- trinucleotide repeat containing 13
- trinucleotide repeat-containing gene 13 protein
- spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2)
- spinocerebellar ataxia 2 homolog
- spinocerebellar ataxia type 2 protein homolog
- ataxin 2
- ataxin-2-like
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