ATRX Produkte
(helicase 2, X-linked (ATRX))
Kategorien
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. The mutations of this gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008].
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Ausgewählte ATRX Kategorien
ATRX Antikörper
High quality antibodies with extensive validation data.
ATRX Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene ATRX Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse
Applikation
WB, IF, IHC (p), ICC, IP
Validierungen
- (7)
Kat. Nr.
ABIN2855005
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, IF, IHC
Validierungen
- (3)
Kat. Nr.
ABIN7172767
Menge
100 μg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
ELISA, WB, IHC, FACS, ICC, Neut
Validierungen
- (3)
Kat. Nr.
ABIN5611354
Menge
0.1 mg
Datenblatt
Datenblatt
Empfohlene ATRX Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346185
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1346187
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Macropus eugenii
Source
Yeast
Validierungen
Kat. Nr.
ABIN1609565
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren ATRX Produkten
: "Telomere elongation via alternative lengthening of telomeres (ALT) and telomerase activation in primary metastatic medulloblastoma of childhood." in: Journal of neuro-oncology, Vol. 142, Issue 3, pp. 435-444, (2019) (PubMed).: "A potential common role of the Jumonji C domain-containing 1A histone demethylase and chromatin remodeler ATRX in promoting colon cancer." in: Oncology letters, Vol. 16, Issue 5, pp. 6652-6662, (2018) (PubMed).
: "Dysregulation of select ATP-dependent chromatin remodeling factors in high trait anxiety." in: Behavioural brain research, Vol. 311, pp. 141-6, (2016) (PubMed).
: "Whole-exome sequencing identifies somatic ATRX mutations in pheochromocytomas and paragangliomas." in: Nature communications, Vol. 6, pp. 6140, (2015) (PubMed).
: "Molecular-genetic and clinical characteristics of gliomas with astrocytic appearance and total 1p19q loss in a single institutional consecutive cohort." in: Oncotarget, Vol. 6, Issue 18, pp. 15871-81, (2015) (PubMed).
: "ATRX represses alternative lengthening of telomeres." in: Oncotarget, Vol. 6, Issue 18, pp. 16543-58, (2015) (PubMed).
: "TERT promoter mutations are frequent and show association with MED12 mutations in phyllodes tumors of the breast." in: British journal of cancer, Vol. 113, Issue 8, pp. 1244-8, (2015) (PubMed).
: "Impaired Contextual Fear Extinction Learning is Associated with Aberrant Regulation of CHD-Type Chromatin Remodeling Factors." in: Frontiers in behavioral neuroscience, Vol. 9, pp. 313, (2015) (PubMed).
: "Benefit from procarbazine, lomustine, and vincristine in oligodendroglial tumors is associated with mutation of IDH." in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 32, Issue 8, pp. 783-90, (2014) (PubMed).
: "Clinical Neuropathology practice news 2-2014: ATRX, a new candidate biomarker in gliomas." in: Clinical neuropathology, Vol. 33, Issue 2, pp. 108-11, (2014) (PubMed).
Synonyme und alternative Namen zu ATRX
ATRX, chromatin remodeler (ATRX), ATRX, chromatin remodeler (Atrx), alpha thalassemia/mental retardation syndrome X-linked L homeolog (atrx.L), alpha thalassemia/mental retardation syndrome X-linked homolog (human) (atrx), 4833408C14Rik, AI447451, ATR2, atrx, atrxl, DXHXS6677E, HP1-BP38, Hp1bp2, Hp1bp38, JMS, MRXHF1, MRXS3, RAD54, Rad54, rad54, RAD54L, SFM1, SHS, wu:fb26e12, wu:fb52h08, wu:fb72g09, wu:fb94e07, XH2, XNP, Xnp, zgc:66223, ZNF-HXBezeichner auf Proteinebene für ATRX
- ATP-dependent helicase ATRX
- DNA dependent ATPase and helicase
- X-linked helicase II
- X-linked nuclear protein
- Zinc finger helicase
- alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog, S. cerevisiae)
- helicase 2, X-linked
- transcriptional regulator ATRX
- HP1 alpha-interacting protein
- alpha thalassemia/mental retardation syndrome (X-linked)
- heterochromatin protein 2
- alpha thalassemia/mental retardation syndrome X-linked homolog
- helicase II
- pABP-2
- XNP
- alpha thalassemia/mental retardation syndrome X-linked (RAD54 homolog)
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